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- W2093405787 abstract "Objective: To compare the long-term (1 year) effects of flutamide (250 mg/d) and finasteride (5 mg/d) for the treatment of hirsutism in women.Design: Randomized, prospective clinical study.Setting: Departments of Gynecology and Obstetrics and Endocrinology at Erciyes University Medical Faculty, Kayseri, Turkey.Patient(s): Seventy patients with hirsutism were studied.Intervention(s): Thirty-five patients were treated with flutamide (250 mg/d) and 35 patients with finasteride (5 mg/d) for 12 months. Hirsutism score, hormone levels, and multiscreen blood chemistry were measured at 3-month intervals.Main Outcome Measure(s): Reduction in hair growth.Result(s): The modified Ferriman-Gallwey scores for hirsutism decreased significantly at months 6 and 12 from a mean ± SD of 17.8 ± 5.8 to 6.0 ± 3.4 and 17.8 ± 5.8 to 4.8 ± 3.2, respectively, in group 1; and from 19.1 ± 6.1 to 14.2 ± 4.9 and 19.1 ± 6.1 to 11.3 ± 5.0 in group 2, respectively. There were no statistically significant differences in any of the hormonal indices in group 1, but in group 2, E2 and sex hormone-binding globulin increased significantly while DHEAS decreased significantly at 12 months of therapy.Conclusion(s): This study shows that flutamide (250 mg/d) is more effective than finasteride (5 mg/d) in reducing hair growth. We conclude that flutamide (250 mg/d) may represent a more effective and well tolerated treatment for patients." @default.
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- W2093405787 date "2007-10-01" @default.
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- W2093405787 title "P.1.g.012 Neurocognition in patients with bipolar type I disorder in remission: relation between vitamin B12 and folic acid" @default.
- W2093405787 doi "https://doi.org/10.1016/s0924-977x(07)70438-8" @default.
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