FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093417165> ?p ?o ?g. }

• W2093417165 endingPage "887" @default.
• W2093417165 startingPage "879" @default.
• W2093417165 abstract "Altered self-antigen processing/presentation of apoptotic cells by DCs and/or modifications of autoantigens may lead to the development of autoantibodies. Increasing evidence indicates that platelets may undergo apoptosis. Therefore, in the present study we investigated whether platelet apoptosis and/or dendritic cells (DCs) may play a role in the stimulation of the immuno-mediated anti-platelet response in chronic immune thrombocytopenic purpura (ITP).Twenty-nine patients with active ITP and 29 healthy adult volunteers were enrolled into the study. Freshly washed platelets and platelets aged in a plasma-free buffer for 72 hours at 37 degrees C were assessed by flow cytometry for phosphatidylserine exposure using annexin V-FITC, caspase activation, and platelet activation markers. CD14-derived DCs were characterized by immunophenotyping, cytokine production, and ability to present fresh and aged platelets to T lymphocytes. We demonstrated that platelets from ITP patients, either fresh or in vitro aged, show increased apoptosis (with low levels of activation) in comparison to their normal counterparts. We also found that immature DCs readily ingest apoptotic platelets. Furthermore, in ITP patients DCs, prepulsed with autologous/allogeneic fresh and aged platelets, are highly efficient in stimulating autologous T-cell proliferation as compared to DCs derived from healthy donors. This finding may be related to the upregulated expression of CD86 in DCs from ITP patients and not to higher phagocytic activity.These results suggest that DC dysfunction, together with increased propensity of platelets to undergo apoptosis, may play a role in the stimulation of the immune system in ITP." @default.
• W2093417165 created "2016-06-24" @default.
• W2093417165 creator A5009267255 @default.
• W2093417165 creator A5018652598 @default.
• W2093417165 creator A5018987163 @default.
• W2093417165 creator A5033359713 @default.
• W2093417165 creator A5044224344 @default.
• W2093417165 creator A5045651843 @default.
• W2093417165 creator A5060757512 @default.
• W2093417165 creator A5064800315 @default.
• W2093417165 creator A5067954471 @default.
• W2093417165 creator A5072253025 @default.
• W2093417165 creator A5074914370 @default.
• W2093417165 creator A5085520305 @default.
• W2093417165 creator A5085994414 @default.
• W2093417165 creator A5090502867 @default.
• W2093417165 date "2006-07-01" @default.
• W2093417165 modified "2023-10-11" @default.
• W2093417165 title "Dendritic cells of immune thrombocytopenic purpura (ITP) show increased capacity to present apoptotic platelets to T lymphocytes" @default.
• W2093417165 cites W1541901307 @default.
• W2093417165 cites W1561516029 @default.
• W2093417165 cites W1561591381 @default.
• W2093417165 cites W1601529928 @default.
• W2093417165 cites W1722018986 @default.
• W2093417165 cites W1977557166 @default.
• W2093417165 cites W199346607 @default.
• W2093417165 cites W1999934400 @default.
• W2093417165 cites W2005613711 @default.
• W2093417165 cites W2007878758 @default.
• W2093417165 cites W2008304542 @default.
• W2093417165 cites W2012748964 @default.
• W2093417165 cites W2013592163 @default.
• W2093417165 cites W2013850946 @default.
• W2093417165 cites W2014207233 @default.
• W2093417165 cites W2015948321 @default.
• W2093417165 cites W2019858566 @default.
• W2093417165 cites W2025064238 @default.
• W2093417165 cites W2030268510 @default.
• W2093417165 cites W2034893493 @default.
• W2093417165 cites W2035488561 @default.
• W2093417165 cites W2039386747 @default.
• W2093417165 cites W2043418529 @default.
• W2093417165 cites W2052853635 @default.
• W2093417165 cites W2053849689 @default.
• W2093417165 cites W2058437162 @default.
• W2093417165 cites W2059698605 @default.
• W2093417165 cites W2059792374 @default.
• W2093417165 cites W2060998877 @default.
• W2093417165 cites W2061506092 @default.
• W2093417165 cites W2065907531 @default.
• W2093417165 cites W2069539210 @default.
• W2093417165 cites W2071782007 @default.
• W2093417165 cites W2082400158 @default.
• W2093417165 cites W2086176990 @default.
• W2093417165 cites W2089126668 @default.
• W2093417165 cites W2090855399 @default.
• W2093417165 cites W2091493364 @default.
• W2093417165 cites W2091695712 @default.
• W2093417165 cites W2093860835 @default.
• W2093417165 cites W2094229990 @default.
• W2093417165 cites W2094758239 @default.
• W2093417165 cites W2096688510 @default.
• W2093417165 cites W2096984260 @default.
• W2093417165 cites W2098031206 @default.
• W2093417165 cites W2099074476 @default.
• W2093417165 cites W2099149994 @default.
• W2093417165 cites W2113400076 @default.
• W2093417165 cites W2118316119 @default.
• W2093417165 cites W2119214100 @default.
• W2093417165 cites W2119975110 @default.
• W2093417165 cites W2127123920 @default.
• W2093417165 cites W2127440907 @default.
• W2093417165 cites W2131014897 @default.
• W2093417165 cites W2131136878 @default.
• W2093417165 cites W2138212565 @default.
• W2093417165 cites W2140582776 @default.
• W2093417165 cites W2142812740 @default.
• W2093417165 cites W2145473252 @default.
• W2093417165 cites W2148345396 @default.
• W2093417165 cites W2155774391 @default.
• W2093417165 cites W2157825858 @default.
• W2093417165 cites W2161118718 @default.
• W2093417165 cites W2166291746 @default.
• W2093417165 cites W2167414668 @default.
• W2093417165 cites W2227401587 @default.
• W2093417165 cites W2254065586 @default.
• W2093417165 cites W2328980622 @default.
• W2093417165 cites W4232025330 @default.
• W2093417165 cites W4313331874 @default.
• W2093417165 doi "https://doi.org/10.1016/j.exphem.2006.03.009" @default.
• W2093417165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16797415" @default.
• W2093417165 hasPublicationYear "2006" @default.
• W2093417165 type Work @default.
• W2093417165 sameAs 2093417165 @default.
• W2093417165 citedByCount "84" @default.
• W2093417165 countsByYear W20934171652012 @default.
• W2093417165 countsByYear W20934171652013 @default.
• W2093417165 countsByYear W20934171652014 @default.

• next