Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093432151> ?p ?o ?g. }
- W2093432151 abstract "Despite extensive efforts, pancreatic cancer remains incurable. Most risk factors, such as genetic disposition, metabolic diseases or chronic pancreatitis cannot be influenced. By contrast, cigarette smoking, an important risk factor for pancreatic cancer, can be controlled. Despite the epidemiological evidence of the detrimental effects of cigarette smoking with regard to pancreatic cancer development and its unique property of being influenceable, our understanding of cigarette smoke-induced pancreatic carcinogenesis is limited. Current data on cigarette smoke-induced pancreatic carcinogenesis indicate multifactorial events that are triggered by nicotine, which is the major pharmacologically active constituent of tobacco smoke. In addition to nicotine, a vast number of carcinogens have the potential to reach the pancreatic gland, where they are metabolized, in some instances to even more toxic compounds. These metabolic events are not restricted to pancreatic ductal cells. Several studies show that acinar cells are also greatly affected. Furthermore, pancreatic cancer progenitor cells do not only derive from the ductal epithelial lineage, but also from acinar cells. This sheds new light on cigarette smoke-induced acinar cell damage. On this background, our objective is to outline a multifactorial model of tobacco smoke-induced pancreatic carcinogenesis." @default.
- W2093432151 created "2016-06-24" @default.
- W2093432151 creator A5011842608 @default.
- W2093432151 creator A5015868168 @default.
- W2093432151 creator A5032515123 @default.
- W2093432151 creator A5043100736 @default.
- W2093432151 creator A5047423734 @default.
- W2093432151 creator A5085256777 @default.
- W2093432151 date "2012-03-23" @default.
- W2093432151 modified "2023-10-12" @default.
- W2093432151 title "The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)" @default.
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