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- W2093444372 abstract "A bstract : Neuroglobin (Ngb) is a newly discovered hexacoordinate globin that is expressed in vertebrate brain and can reversibly bind oxygen. Expression of Ngb increases in response to oxygen deprivation and protects neurons from hypoxia in vitro and in vivo . Recent work on human Ngb has shed light on the mechanism of this neuroprotection by human Ngb, as discussed in this review. Human ferric Ngb has been found to act as a guanine nucleotide dissociation inhibitor for the α subunit of heterotrimeric G proteins. Moreover, other Ngb‐binding proteins also have been identified. These findings suggest that human Ngb may function as a regulator of signal transduction in the brain." @default.
- W2093444372 created "2016-06-24" @default.
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- W2093444372 date "2005-08-01" @default.
- W2093444372 modified "2023-10-17" @default.
- W2093444372 title "Possible Neuroprotective Mechanism of Human Neuroglobin" @default.
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- W2093444372 doi "https://doi.org/10.1111/j.1749-6632.2005.tb00028.x" @default.
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