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• W2093446800 abstract "Xib, a gene recently reported to reside on the q28 region of the human X chromosome [Pergolizzi et al. (1996) Gene 168, 267-270], contains an open reading frame homologous to those of the DNase I family enzymes. The full open reading frame of this gene has been fused to the E. coli gene of the maltose binding protein and expressed in bacteria as a chimeric protein. The partially purified chimeric protein is enzymatically active. It introduces single and double stranded breaks into supercoiled DNA, at 30 degrees C in the absence of divalent cations and at a pH optimum of 5.2. To our knowledge this enzyme represents the first cloned human endonuclease with characteristics similar to those of acidic DNase II." @default.
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• W2093446800 date "1997-03-01" @default.
• W2093446800 modified "2023-10-13" @default.
• W2093446800 title "Functional characterization of a human DNase-like protein encoded by a gene positioned in Xq28" @default.
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• W2093446800 doi "https://doi.org/10.1016/s0378-1119(96)00794-9" @default.
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