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• W2093451285 abstract "Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. CA may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis." @default.
• W2093451285 created "2016-06-24" @default.
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• W2093451285 date "2015-04-10" @default.
• W2093451285 modified "2023-10-14" @default.
• W2093451285 title "The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions" @default.
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• W2093451285 doi "https://doi.org/10.1038/srep09642" @default.
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