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- W2093453013 abstract "Cardiac protein synthesis has been found to increase as pressure stress is applied both in vivo and in vitro, but the relationship between contraction, per se, and protein synthesis has not been characterized. A cardiac preparation with right ventricular loading and controlled coronary flow was used to examine the possibility of such a relation, in vitro. In both aerobically perfused contracting and high K+ arrested hearts, ATP, creatine phosphate, potassium and glycogen levels were maintained, and lactate production was at low levels. Incorporation of [14C]lysine into right and left ventricular protein was the same in contracting and aerobically perfused arrested hearts after 3 h of perfusion. In contrast, anoxia induced arrest decreased incorporation of lysine into protein with a more profound drop in [14C]lysine incorporation in the left ventricle. Alterations of protein synthesis in 3 h of anoxia were associated with a fall in ATP (greater in the left ventricle than in the right ventricle), creatine phosphate, glycogen and potassium with a sharp rise in lactate production. These changes in anoxia were minimized when anoxic hearts were concomitantly perfused with high K+ (16 mEq/l). The data indicate that cardiac arrest associated with metabolic integrity in this preparation produced little change in protein synthesis and suggest that a baseline rate of protein synthesis occurs in such tissue which is not dependent on contraction, per se." @default.
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- W2093453013 date "1977-02-01" @default.
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- W2093453013 title "Protein synthesis in prolonged cardiac arrest" @default.
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- W2093453013 doi "https://doi.org/10.1016/0022-2828(77)90042-6" @default.
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