FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093464694> ?p ?o ?g. }

• W2093464694 endingPage "e5169" @default.
• W2093464694 startingPage "e5169" @default.
• W2093464694 abstract "The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain (LC) that forms amyloid deposits. Somatic mutations in AL LCs make these proteins less thermodynamically stable than their non-amyloidogenic counterparts, leading to misfolding and ultimately the formation of amyloid fibrils. We hypothesize that location rather than number of non-conservative mutations determines the amyloidogenicity of light chains.We performed sequence alignments on the variable domain of 50 kappa and 91 lambda AL light chains and calculated the number of non-conservative mutations over total number of patients for each secondary structure element in order to identify regions that accumulate non-conservative mutations. Among patients with AL, the levels of circulating immunoglobulin free light chain varies greatly, but even patients with very low levels can have very advanced amyloid deposition.Our results show that in specific secondary structure elements, there are significant differences in the number of non-conservative mutations between normal and AL sequences. AL sequences from patients with different levels of secreted light chain have distinct differences in the location of non-conservative mutations, suggesting that for patients with very low levels of light chains and advanced amyloid deposition, the location of non-conservative mutations rather than the amount of free light chain in circulation may determine the amyloidogenic propensity of light chains." @default.
• W2093464694 created "2016-06-24" @default.
• W2093464694 creator A5000308170 @default.
• W2093464694 creator A5006035574 @default.
• W2093464694 creator A5016853434 @default.
• W2093464694 creator A5066690948 @default.
• W2093464694 creator A5072543002 @default.
• W2093464694 creator A5072545885 @default.
• W2093464694 date "2009-04-13" @default.
• W2093464694 modified "2023-10-13" @default.
• W2093464694 title "Mutations in Specific Structural Regions of Immunoglobulin Light Chains Are Associated with Free Light Chain Levels in Patients with AL Amyloidosis" @default.
• W2093464694 cites W1519342464 @default.
• W2093464694 cites W1964172606 @default.
• W2093464694 cites W1967773653 @default.
• W2093464694 cites W1972305321 @default.
• W2093464694 cites W1980508578 @default.
• W2093464694 cites W1997280623 @default.
• W2093464694 cites W1997887926 @default.
• W2093464694 cites W2002559713 @default.
• W2093464694 cites W2009947511 @default.
• W2093464694 cites W2029035889 @default.
• W2093464694 cites W2044170723 @default.
• W2093464694 cites W2044223958 @default.
• W2093464694 cites W2049103250 @default.
• W2093464694 cites W2063939741 @default.
• W2093464694 cites W2076119439 @default.
• W2093464694 cites W2077174198 @default.
• W2093464694 cites W2077274888 @default.
• W2093464694 cites W2087770415 @default.
• W2093464694 cites W2088416614 @default.
• W2093464694 cites W2107104642 @default.
• W2093464694 cites W2108353209 @default.
• W2093464694 cites W2158749981 @default.
• W2093464694 cites W2171160798 @default.
• W2093464694 cites W2979646088 @default.
• W2093464694 cites W86094332 @default.
• W2093464694 doi "https://doi.org/10.1371/journal.pone.0005169" @default.
• W2093464694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2664898" @default.
• W2093464694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19365555" @default.
• W2093464694 hasPublicationYear "2009" @default.
• W2093464694 type Work @default.
• W2093464694 sameAs 2093464694 @default.
• W2093464694 citedByCount "71" @default.
• W2093464694 countsByYear W20934646942012 @default.
• W2093464694 countsByYear W20934646942013 @default.
• W2093464694 countsByYear W20934646942014 @default.
• W2093464694 countsByYear W20934646942015 @default.
• W2093464694 countsByYear W20934646942016 @default.
• W2093464694 countsByYear W20934646942017 @default.
• W2093464694 countsByYear W20934646942018 @default.
• W2093464694 countsByYear W20934646942019 @default.
• W2093464694 countsByYear W20934646942020 @default.
• W2093464694 countsByYear W20934646942021 @default.
• W2093464694 countsByYear W20934646942022 @default.
• W2093464694 countsByYear W20934646942023 @default.
• W2093464694 crossrefType "journal-article" @default.
• W2093464694 hasAuthorship W2093464694A5000308170 @default.
• W2093464694 hasAuthorship W2093464694A5006035574 @default.
• W2093464694 hasAuthorship W2093464694A5016853434 @default.
• W2093464694 hasAuthorship W2093464694A5066690948 @default.
• W2093464694 hasAuthorship W2093464694A5072543002 @default.
• W2093464694 hasAuthorship W2093464694A5072545885 @default.
• W2093464694 hasBestOaLocation W20934646941 @default.
• W2093464694 hasConcept C104317684 @default.
• W2093464694 hasConcept C142724271 @default.
• W2093464694 hasConcept C159654299 @default.
• W2093464694 hasConcept C179104552 @default.
• W2093464694 hasConcept C185592680 @default.
• W2093464694 hasConcept C2777633098 @default.
• W2093464694 hasConcept C2779551797 @default.
• W2093464694 hasConcept C2779951007 @default.
• W2093464694 hasConcept C36394416 @default.
• W2093464694 hasConcept C501734568 @default.
• W2093464694 hasConcept C54355233 @default.
• W2093464694 hasConcept C55493867 @default.
• W2093464694 hasConcept C71924100 @default.
• W2093464694 hasConcept C86803240 @default.
• W2093464694 hasConceptScore W2093464694C104317684 @default.
• W2093464694 hasConceptScore W2093464694C142724271 @default.
• W2093464694 hasConceptScore W2093464694C159654299 @default.
• W2093464694 hasConceptScore W2093464694C179104552 @default.
• W2093464694 hasConceptScore W2093464694C185592680 @default.
• W2093464694 hasConceptScore W2093464694C2777633098 @default.
• W2093464694 hasConceptScore W2093464694C2779551797 @default.
• W2093464694 hasConceptScore W2093464694C2779951007 @default.
• W2093464694 hasConceptScore W2093464694C36394416 @default.
• W2093464694 hasConceptScore W2093464694C501734568 @default.
• W2093464694 hasConceptScore W2093464694C54355233 @default.
• W2093464694 hasConceptScore W2093464694C55493867 @default.
• W2093464694 hasConceptScore W2093464694C71924100 @default.
• W2093464694 hasConceptScore W2093464694C86803240 @default.
• W2093464694 hasIssue "4" @default.
• W2093464694 hasLocation W20934646941 @default.
• W2093464694 hasLocation W20934646942 @default.
• W2093464694 hasLocation W20934646943 @default.
• W2093464694 hasLocation W20934646944 @default.
• W2093464694 hasOpenAccess W2093464694 @default.
• W2093464694 hasPrimaryLocation W20934646941 @default.

• next