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• W2093477029 abstract "1 Dopexamine is an agonist at peripheral dopamine receptors and at β2-adrenoceptors. 2 Dopexamine has approximately one-third the potency of dopamine in stimulating the vascular DA1-receptor in the dog, resulting in a fall in renal vascular resistance of 20% at 2.3 × 10−8 mol kg−1 (i.a.). 3 Prejunctional DA2-receptors are also stimulated by dopexamine, resulting in a reduction of neurogenic vasoconstriction in the rabbit isolated ear artery (IC50 of 1.15 × 10−6 M) and of neurogenic tachycardia in the cat (ID50 of 5.4 × 10−8 mol kg−1, i.v.), with a potency six and four times less respectively than that of dopamine. 4 By contrast, dopexamine is approximately 60 times more potent than dopamine as an agonist at the β2-adrenoceptor of the guinea-pig isolated tracheal chain, with an EC50 of 1.5 × 10−6 M. 5 Both dopexamine and dopamine are weak agonists at the guinea-pig atrial β1-adrenoceptor over the concentration range 10−7 to 10−4 M, but dopexamine has an intrinsic activity of only 0.16 relative to dopamine. 6 Dopexamine does not stimulate postjunctional α1 or α2-adrenoceptors in the canine isolated saphenous vein, whereas dopamine is an agonist, approximately 120 times less potent than noradrenaline. 7 Unlike dopamine and salbutamol, dopexamine does not cause arrhythmias in the guinea-pig isolated perfused heart at doses of up to 10−5 mol, which is a thousand times the minimum cardiostimulant dose. 8 The combination of agonist properties at peripheral dopamine receptors and at β2-adrenoceptors, with little or no activity at α- and β1-adrenoceptors gives dopexamine a novel pharmacological profile. This may confer advantages over dopamine in the treatment of acute heart failure." @default.
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• W2093477029 date "1985-07-01" @default.
• W2093477029 modified "2023-09-26" @default.
• W2093477029 title "Dopexamine: a novel agonist at peripheral dopamine receptors and β2-adrenoceptors" @default.
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• W2093477029 doi "https://doi.org/10.1111/j.1476-5381.1985.tb10554.x" @default.
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