FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093477946> ?p ?o ?g. }

• W2093477946 endingPage "645" @default.
• W2093477946 startingPage "638" @default.
• W2093477946 abstract "The receptor for hyaluronan-mediated motility (RHAMM) is frequently overexpressed in brain tumors and was recently identified as an immunogenic antigen by using serological screening of cDNA expression libraries. In this study, which was conducted using a mouse glioma model, the authors tested the hypothesis that vaccination with dendritic cells transfected with RHAMM mRNA induces strong immunological antitumor effects.The authors constructed a plasmid for transduction of the mRNAs transcribed in vitro into dendritic cells, which were then used to transport the intracellular protein RHAMM efficiently into major histocompatibility complex class II compartments by adding a late endosomal-lysosomal sorting signal to the RHAMM gene. The dendritic cells transfected with this RHAMM mRNA were injected intraperitoneally into the mouse glioma model 3 and 10 days after tumor cell implantation. The antitumor effects of the vaccine were estimated by the survival rate, histological analysis, and immunohistochemical findings for immune cells. Mice in the group treated by vaccination therapy with dendritic cells transfected with RHAMM mRNA survived significantly longer than those in the control groups. Immunohistochemical analysis revealed that greater numbers of T lymphocytes containing T cells activated by CD4+, CD8+, and CD25+ were found in the group vaccinated with dendritic cells transfected with RHAMM mRNA.These results demonstrate the therapeutic potential of vaccination with dendritic cells transfected with RHAMM mRNA for the treatment of malignant glioma." @default.
• W2093477946 created "2016-06-24" @default.
• W2093477946 creator A5000597691 @default.
• W2093477946 creator A5000893018 @default.
• W2093477946 creator A5004215583 @default.
• W2093477946 creator A5014355327 @default.
• W2093477946 creator A5019150698 @default.
• W2093477946 creator A5033584393 @default.
• W2093477946 creator A5058860643 @default.
• W2093477946 creator A5065435032 @default.
• W2093477946 creator A5066123698 @default.
• W2093477946 creator A5072437205 @default.
• W2093477946 creator A5081923476 @default.
• W2093477946 date "2007-04-01" @default.
• W2093477946 modified "2023-10-18" @default.
• W2093477946 title "Antitumor effects of vaccination with dendritic cells transfected with modified receptor for hyaluronan-mediated motility mRNA in a mouse glioma model" @default.
• W2093477946 cites W1495551511 @default.
• W2093477946 cites W1498287170 @default.
• W2093477946 cites W185680628 @default.
• W2093477946 cites W1966552141 @default.
• W2093477946 cites W1970123816 @default.
• W2093477946 cites W1992768182 @default.
• W2093477946 cites W2001197606 @default.
• W2093477946 cites W2011899782 @default.
• W2093477946 cites W2014707283 @default.
• W2093477946 cites W2024330264 @default.
• W2093477946 cites W2026444291 @default.
• W2093477946 cites W2036678109 @default.
• W2093477946 cites W2036876584 @default.
• W2093477946 cites W2038210916 @default.
• W2093477946 cites W2044949794 @default.
• W2093477946 cites W2045291287 @default.
• W2093477946 cites W2051648790 @default.
• W2093477946 cites W2057359507 @default.
• W2093477946 cites W2064326439 @default.
• W2093477946 cites W2069033341 @default.
• W2093477946 cites W2078656693 @default.
• W2093477946 cites W2078816587 @default.
• W2093477946 cites W2080368646 @default.
• W2093477946 cites W2090464403 @default.
• W2093477946 cites W2090774807 @default.
• W2093477946 cites W2095825164 @default.
• W2093477946 cites W2099247844 @default.
• W2093477946 cites W2107480940 @default.
• W2093477946 cites W2118701824 @default.
• W2093477946 cites W2130725713 @default.
• W2093477946 cites W2134403422 @default.
• W2093477946 cites W2137094106 @default.
• W2093477946 cites W2138773604 @default.
• W2093477946 cites W2148680076 @default.
• W2093477946 cites W2164377001 @default.
• W2093477946 cites W2168053705 @default.
• W2093477946 cites W2207546997 @default.
• W2093477946 cites W2317464480 @default.
• W2093477946 cites W2320772875 @default.
• W2093477946 doi "https://doi.org/10.3171/jns.2007.106.4.638" @default.
• W2093477946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17432716" @default.
• W2093477946 hasPublicationYear "2007" @default.
• W2093477946 type Work @default.
• W2093477946 sameAs 2093477946 @default.
• W2093477946 citedByCount "23" @default.
• W2093477946 countsByYear W20934779462012 @default.
• W2093477946 countsByYear W20934779462014 @default.
• W2093477946 countsByYear W20934779462015 @default.
• W2093477946 countsByYear W20934779462016 @default.
• W2093477946 countsByYear W20934779462020 @default.
• W2093477946 countsByYear W20934779462021 @default.
• W2093477946 countsByYear W20934779462022 @default.
• W2093477946 countsByYear W20934779462023 @default.
• W2093477946 crossrefType "journal-article" @default.
• W2093477946 hasAuthorship W2093477946A5000597691 @default.
• W2093477946 hasAuthorship W2093477946A5000893018 @default.
• W2093477946 hasAuthorship W2093477946A5004215583 @default.
• W2093477946 hasAuthorship W2093477946A5014355327 @default.
• W2093477946 hasAuthorship W2093477946A5019150698 @default.
• W2093477946 hasAuthorship W2093477946A5033584393 @default.
• W2093477946 hasAuthorship W2093477946A5058860643 @default.
• W2093477946 hasAuthorship W2093477946A5065435032 @default.
• W2093477946 hasAuthorship W2093477946A5066123698 @default.
• W2093477946 hasAuthorship W2093477946A5072437205 @default.
• W2093477946 hasAuthorship W2093477946A5081923476 @default.
• W2093477946 hasBestOaLocation W20934779461 @default.
• W2093477946 hasConcept C153911025 @default.
• W2093477946 hasConcept C167672396 @default.
• W2093477946 hasConcept C203014093 @default.
• W2093477946 hasConcept C2778170410 @default.
• W2093477946 hasConcept C2778227246 @default.
• W2093477946 hasConcept C502942594 @default.
• W2093477946 hasConcept C54009773 @default.
• W2093477946 hasConcept C54355233 @default.
• W2093477946 hasConcept C71924100 @default.
• W2093477946 hasConcept C81885089 @default.
• W2093477946 hasConcept C86803240 @default.
• W2093477946 hasConcept C8891405 @default.
• W2093477946 hasConceptScore W2093477946C153911025 @default.
• W2093477946 hasConceptScore W2093477946C167672396 @default.
• W2093477946 hasConceptScore W2093477946C203014093 @default.
• W2093477946 hasConceptScore W2093477946C2778170410 @default.

• next