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• W2093479877 abstract "The visual detection of specific double-stranded DNA sequences possesses great potential for the development of diagnostics. Zinc finger domains provide a powerful scaffold for creating custom DNA-binding proteins that recognize specific DNA sequences. We previously demonstrated sequence-enabled reassembly of TEM-1 β-lactamase (SEER-LAC), a system consisting of two inactive fragments of β-lactamase each linked to engineered zinc finger proteins (ZFPs). Here the SEER-LAC system was applied to develop ZFP arrays that function as simple devices to identify bacterial double-stranded DNA sequences. The ZFP arrays provided a quantitative assay with a detection limit of 50 fmol of target DNA. The method could distinguish target DNA from non-target DNA within 5 min. The ZFP arrays provided sufficient sensitivity and high specificity to recognize specific DNA sequences. These results suggest that ZFP arrays have the potential to be developed into a simple and rapid point-of-care (POC) diagnostic for the multiplexed detection of pathogens." @default.
• W2093479877 created "2016-06-24" @default.
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• W2093479877 date "2010-12-05" @default.
• W2093479877 modified "2023-09-26" @default.
• W2093479877 title "A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications" @default.
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• W2093479877 doi "https://doi.org/10.1093/nar/gkq1214" @default.
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