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• W2093480293 abstract "SUMMARY Chronic increases in circulating corticosterone (CORT) generally suppress immune function, but it is not known whether evolved increases necessarily have similar adverse effects. Moreover, the evolution of immune function might be constrained by the sharing of signaling molecules, such as CORT, across numerous physiological systems. Laboratory house mice (Mus domesticus Linnaeus) from four replicate lines selectively bred for high voluntary wheel running (HR lines) generally had baseline circulating CORT approximately twofold higher than in four non-selected control (C) lines. To test whether elevated baseline CORT suppresses the inflammatory response in HR mice, we injected females with lipopolysaccharide (LPS). All mice injected with LPS exhibited classic signs of an inflammatory response, including sickness behavior, loss of body mass, reduced locomotor activity (i.e. voluntary wheel running), enlarged spleens and livers, elevated hematocrit and elevated inflammatory cytokines. However, as compared with C mice, the inflammatory response was not suppressed in HR mice. Our results, and those of a previous study, suggest that selective breeding for high voluntary exercise has not altered immune function. They also suggest that the effects of evolved differences in baseline CORT levels may differ greatly from effects of environmental factors (often viewed as ‘stressors’) that alter baseline CORT during an individual’s lifetime. In particular, evolved increases in circulating levels of ‘stress hormones’ are not necessarily associated with detrimental suppression of the inflammatory response, presumably as a result of correlated evolution of other physiological systems (counter-measures). Our results have important implications for the interpretation of elevated stress hormones and of immune indicators in natural populations." @default.
• W2093480293 created "2016-06-24" @default.
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• W2093480293 date "2012-05-15" @default.
• W2093480293 modified "2023-09-25" @default.
• W2093480293 title "Within-lifetime trade-offs but evolutionary freedom for hormonal and immunological traits: evidence from mice bred for high voluntary exercise" @default.
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• W2093480293 cites W1607092491 @default.
• W2093480293 cites W1903848026 @default.
• W2093480293 cites W1965635919 @default.
• W2093480293 cites W1968014809 @default.
• W2093480293 cites W1968404427 @default.
• W2093480293 cites W1974256277 @default.
• W2093480293 cites W1975636294 @default.
• W2093480293 cites W1981286603 @default.
• W2093480293 cites W1981748148 @default.
• W2093480293 cites W1981789138 @default.
• W2093480293 cites W1986411624 @default.
• W2093480293 cites W1987150557 @default.
• W2093480293 cites W1990655979 @default.
• W2093480293 cites W1997336261 @default.
• W2093480293 cites W1998198644 @default.
• W2093480293 cites W2000942130 @default.
• W2093480293 cites W2005638112 @default.
• W2093480293 cites W2009403649 @default.
• W2093480293 cites W2009550948 @default.
• W2093480293 cites W2014247660 @default.
• W2093480293 cites W2017421512 @default.
• W2093480293 cites W2017977145 @default.
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• W2093480293 cites W2041352234 @default.
• W2093480293 cites W2043496342 @default.
• W2093480293 cites W2047820724 @default.
• W2093480293 cites W2048047184 @default.
• W2093480293 cites W2051558840 @default.
• W2093480293 cites W2053994274 @default.
• W2093480293 cites W2064985760 @default.
• W2093480293 cites W2068717659 @default.
• W2093480293 cites W2070217535 @default.
• W2093480293 cites W2071265782 @default.
• W2093480293 cites W2079477813 @default.
• W2093480293 cites W2090745528 @default.
• W2093480293 cites W2096260958 @default.
• W2093480293 cites W2099555137 @default.
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• W2093480293 doi "https://doi.org/10.1242/jeb.066167" @default.
• W2093480293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22539732" @default.
• W2093480293 hasPublicationYear "2012" @default.
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