FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093480304> ?p ?o ?g. }

• W2093480304 endingPage "998" @default.
• W2093480304 startingPage "981" @default.
• W2093480304 abstract "Chronic exposure to inorganic arsenic (iAs) is associated with the development of benign and malignant human skin lesions including nonmelanoma skin cancers. The precise arsenical form(s) responsible for this carcinogenic effect are unknown, although trivalent inorganic arsenic (iAs(III)) and two of its toxic metabolites, monomethylarsonous acid (MMA(III)) and methylarsinous acid (DMA(III)), are attractive candidates. In an effort to better understand and compare their toxic effects in the skin, we compared the global gene expression profiles of normal human epidermal keratinocytes (NHEKs) exposed to varying noncytotoxic/slightly cytotoxic concentrations of iAs(III), MMA(III), and DMA(III) for 24 h. Exposure to each arsenical treatment group exhibited a dose effect in the number of altered genes and the magnitude of expression change in NHEKs. The most significant gene expression changes associated with iAs(III) and MMA(III) exposure were consistent with several key events believed to be important to As-driven skin carcinogenesis, namely induction of oxidative stress, increased transcript levels of keratinocyte growth factors, and modulation of MAPK and NF-κB pathways. At both comparable arsenical concentrations and comparable NHEK toxicity, greater potential carcinogenic effects were observed in MMA(III)-exposed NHEKs than those exposed to iAs(III), including involvement of more proinflammatory signals and increased transcript levels of more growth factor genes. In contrast, none of these above-mentioned transcriptional trends were among the most significantly altered functions in the DMA(III) treatment group. This study suggests the relative capacity of each of the tested arsenicals to drive suspected key events in As-mediated skin carcinogenesis is MMA(III) > iAs(III) with little contribution from DMA(III)." @default.
• W2093480304 created "2016-06-24" @default.
• W2093480304 creator A5017127477 @default.
• W2093480304 creator A5063296340 @default.
• W2093480304 creator A5063606524 @default.
• W2093480304 creator A5079700168 @default.
• W2093480304 creator A5086059592 @default.
• W2093480304 date "2010-09-30" @default.
• W2093480304 modified "2023-10-01" @default.
• W2093480304 title "Gene expression of normal human epidermal keratinocytes modulated by trivalent arsenicals" @default.
• W2093480304 cites W117048748 @default.
• W2093480304 cites W1964064152 @default.
• W2093480304 cites W1964171854 @default.
• W2093480304 cites W1966398962 @default.
• W2093480304 cites W1967996072 @default.
• W2093480304 cites W1969795460 @default.
• W2093480304 cites W1972171189 @default.
• W2093480304 cites W1972754197 @default.
• W2093480304 cites W1974187478 @default.
• W2093480304 cites W1974381826 @default.
• W2093480304 cites W1976104819 @default.
• W2093480304 cites W1976341140 @default.
• W2093480304 cites W1977896790 @default.
• W2093480304 cites W1985158717 @default.
• W2093480304 cites W1985869400 @default.
• W2093480304 cites W1989371655 @default.
• W2093480304 cites W1994008801 @default.
• W2093480304 cites W1995335028 @default.
• W2093480304 cites W1995726629 @default.
• W2093480304 cites W1997565776 @default.
• W2093480304 cites W1998577751 @default.
• W2093480304 cites W2000555456 @default.
• W2093480304 cites W2001369026 @default.
• W2093480304 cites W2002476437 @default.
• W2093480304 cites W2002721333 @default.
• W2093480304 cites W2004369036 @default.
• W2093480304 cites W2007620375 @default.
• W2093480304 cites W2007782053 @default.
• W2093480304 cites W2008229855 @default.
• W2093480304 cites W2017370342 @default.
• W2093480304 cites W2018782901 @default.
• W2093480304 cites W2020842094 @default.
• W2093480304 cites W2022553472 @default.
• W2093480304 cites W2025656009 @default.
• W2093480304 cites W2028098070 @default.
• W2093480304 cites W2029499035 @default.
• W2093480304 cites W2035029439 @default.
• W2093480304 cites W2037955609 @default.
• W2093480304 cites W2038673475 @default.
• W2093480304 cites W2042883972 @default.
• W2093480304 cites W2047163415 @default.
• W2093480304 cites W2047439811 @default.
• W2093480304 cites W2048859385 @default.
• W2093480304 cites W2053299183 @default.
• W2093480304 cites W2053325510 @default.
• W2093480304 cites W2055196302 @default.
• W2093480304 cites W2059028667 @default.
• W2093480304 cites W2059841058 @default.
• W2093480304 cites W2063388487 @default.
• W2093480304 cites W2064014129 @default.
• W2093480304 cites W2064343777 @default.
• W2093480304 cites W2074206560 @default.
• W2093480304 cites W2074577245 @default.
• W2093480304 cites W2074585214 @default.
• W2093480304 cites W2082289095 @default.
• W2093480304 cites W2083550082 @default.
• W2093480304 cites W2085054959 @default.
• W2093480304 cites W2086201153 @default.
• W2093480304 cites W2086579338 @default.
• W2093480304 cites W2088686339 @default.
• W2093480304 cites W2090400273 @default.
• W2093480304 cites W2090514887 @default.
• W2093480304 cites W2093366601 @default.
• W2093480304 cites W2098442279 @default.
• W2093480304 cites W2111522563 @default.
• W2093480304 cites W2114918609 @default.
• W2093480304 cites W2115406910 @default.
• W2093480304 cites W2117326659 @default.
• W2093480304 cites W2121684005 @default.
• W2093480304 cites W2124569198 @default.
• W2093480304 cites W2127185984 @default.
• W2093480304 cites W2128822546 @default.
• W2093480304 cites W2129911411 @default.
• W2093480304 cites W2134873387 @default.
• W2093480304 cites W2135699074 @default.
• W2093480304 cites W2137071408 @default.
• W2093480304 cites W2146558971 @default.
• W2093480304 cites W2148733641 @default.
• W2093480304 cites W2153412566 @default.
• W2093480304 cites W2161705855 @default.
• W2093480304 cites W2162114270 @default.
• W2093480304 cites W2165235300 @default.
• W2093480304 doi "https://doi.org/10.1002/mc.20677" @default.
• W2093480304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20886546" @default.
• W2093480304 hasPublicationYear "2010" @default.
• W2093480304 type Work @default.
• W2093480304 sameAs 2093480304 @default.
• W2093480304 citedByCount "23" @default.

• next