Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093485337> ?p ?o ?g. }
- W2093485337 endingPage "311" @default.
- W2093485337 startingPage "303" @default.
- W2093485337 abstract "Gastric epithelial turnover is a dynamic process. It is characterized by continuous cell proliferation, which is counterbalanced by cell loss. The biological principle that mediates the homeostasis of epithelium is programmed cell death, or apoptosis. Currently, several subtypes of apoptosis are distinguished, which are mediated by different mechanisms. Various subtypes of apoptosis also occur in the gastric epithelium under various conditions. In the normal stomach, apoptosis due to cell isolation (anoikis) mediates the physiological epithelial turnover. Albeit rarely seen in routine histology, approximately 2% of epithelial cells in the normal stomach are apoptotic. In Helicobacter pylori-induced gastritis, apoptosis and epithelial proliferation are moderately increased, with approximately 8% apoptotic epithelial cells. In gastritis, factors such as CD95 ligand or tumor necrosis factor (TNF) alpha act as death factors. They bind to specific receptors, CD95 and TNF-R, which are induced either by other cytokines, such as interferon gamma, or by Helicobacter pylori itself. In addition to CD95, H.pylorican also induce upregulation of CD95 ligand expression. Taken together, the upregulated expression of CD95, and the presence of CD95L in the close proximity to apoptotic gastric epithelial cells suggest a functional role of the CD95-CD95L system in the induction of apoptosis in H.pylori-gastritis. The role of other pathways to apoptosis is currently under study. Apart from being a biological phenomenon, apoptosis in the stomach may also have direct clinical consequences. An extreme example is given in gastric graft-vs.-host disease when epithelial denudement occurs." @default.
- W2093485337 created "2016-06-24" @default.
- W2093485337 creator A5041741253 @default.
- W2093485337 creator A5051636223 @default.
- W2093485337 date "2000-03-01" @default.
- W2093485337 modified "2023-10-03" @default.
- W2093485337 title "Role of apoptosis in gastric epithelial turnover" @default.
- W2093485337 cites W10916590 @default.
- W2093485337 cites W117380189 @default.
- W2093485337 cites W1489400525 @default.
- W2093485337 cites W1490480018 @default.
- W2093485337 cites W1491641145 @default.
- W2093485337 cites W1558473055 @default.
- W2093485337 cites W1565750262 @default.
- W2093485337 cites W1589415602 @default.
- W2093485337 cites W1667997885 @default.
- W2093485337 cites W1933287277 @default.
- W2093485337 cites W1963688949 @default.
- W2093485337 cites W1964617786 @default.
- W2093485337 cites W1971271340 @default.
- W2093485337 cites W1980933863 @default.
- W2093485337 cites W1981106016 @default.
- W2093485337 cites W1982728308 @default.
- W2093485337 cites W1986076862 @default.
- W2093485337 cites W1987822516 @default.
- W2093485337 cites W1991865867 @default.
- W2093485337 cites W1995124037 @default.
- W2093485337 cites W1995495149 @default.
- W2093485337 cites W2001357164 @default.
- W2093485337 cites W2001807187 @default.
- W2093485337 cites W2002416520 @default.
- W2093485337 cites W2002503549 @default.
- W2093485337 cites W2002898043 @default.
- W2093485337 cites W2006840853 @default.
- W2093485337 cites W2012433592 @default.
- W2093485337 cites W2021758093 @default.
- W2093485337 cites W2025128734 @default.
- W2093485337 cites W2027391354 @default.
- W2093485337 cites W2029499500 @default.
- W2093485337 cites W2032118879 @default.
- W2093485337 cites W2032334367 @default.
- W2093485337 cites W2034288807 @default.
- W2093485337 cites W2034636174 @default.
- W2093485337 cites W2042826092 @default.
- W2093485337 cites W2044117808 @default.
- W2093485337 cites W2046205790 @default.
- W2093485337 cites W2047490825 @default.
- W2093485337 cites W2049110705 @default.
- W2093485337 cites W2052853635 @default.
- W2093485337 cites W2057558284 @default.
- W2093485337 cites W2059131306 @default.
- W2093485337 cites W2073715494 @default.
- W2093485337 cites W2073723117 @default.
- W2093485337 cites W2073888106 @default.
- W2093485337 cites W2075809552 @default.
- W2093485337 cites W2078297328 @default.
- W2093485337 cites W2080797839 @default.
- W2093485337 cites W2083043624 @default.
- W2093485337 cites W2083560313 @default.
- W2093485337 cites W2085446310 @default.
- W2093485337 cites W2085939516 @default.
- W2093485337 cites W2086654981 @default.
- W2093485337 cites W2094985040 @default.
- W2093485337 cites W2096779083 @default.
- W2093485337 cites W2097984152 @default.
- W2093485337 cites W2098174442 @default.
- W2093485337 cites W2102998161 @default.
- W2093485337 cites W2106835946 @default.
- W2093485337 cites W2107195693 @default.
- W2093485337 cites W2123627682 @default.
- W2093485337 cites W2127258120 @default.
- W2093485337 cites W2132417221 @default.
- W2093485337 cites W2133452916 @default.
- W2093485337 cites W2137022580 @default.
- W2093485337 cites W2138302361 @default.
- W2093485337 cites W2139159719 @default.
- W2093485337 cites W2139993995 @default.
- W2093485337 cites W2146283808 @default.
- W2093485337 cites W2154733085 @default.
- W2093485337 cites W2156315689 @default.
- W2093485337 cites W2161261662 @default.
- W2093485337 cites W2189490860 @default.
- W2093485337 cites W23306615 @default.
- W2093485337 cites W2336449142 @default.
- W2093485337 cites W23550718 @default.
- W2093485337 cites W239461145 @default.
- W2093485337 cites W2439347261 @default.
- W2093485337 cites W2948387191 @default.
- W2093485337 cites W4231856309 @default.
- W2093485337 cites W4237386550 @default.
- W2093485337 cites W69105152 @default.
- W2093485337 doi "https://doi.org/10.1002/(sici)1097-0029(20000301)48:5<303::aid-jemt7>3.0.co;2-x" @default.
- W2093485337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10700047" @default.
- W2093485337 hasPublicationYear "2000" @default.
- W2093485337 type Work @default.
- W2093485337 sameAs 2093485337 @default.
- W2093485337 citedByCount "40" @default.
- W2093485337 countsByYear W20934853372012 @default.