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• W2093486564 endingPage "1" @default.
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• W2093486564 abstract "Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses Catherine Datto,1 Richard Hellmund,1 Mohd Kashif Siddiqui21AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA; 2HERON PVT India, Chandigarh, UT, IndiaAbstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as non-selective NSAIDs (nsNSAIDs) or selective cyclooxygenase-2 (COX-2) inhibitors, are commonly prescribed for arthritic pain relief in patients with osteoarthritis (OA), rheumatoid arthritis (RA), or ankylosing spondylitis (AS). Treatment guidelines for chronic NSAID therapy include the consideration for gastroprotection for those at risk of gastric ulcers (GUs) associated with the chronic NSAID therapy. The United States Food and Drug Administration has approved naproxen/esomeprazole magnesium tablets for the relief of signs and symptoms of OA, RA, and AS, and to decrease the risk of developing GUs in patients at risk of developing NSAID-associated GUs. The European Medical Association has approved this therapy for the symptomatic treatment of OA, RA, and AS in patients who are at risk of developing NSAID-associated GUs and/or duodenal ulcers, for whom treatment with lower doses of naproxen or other NSAIDs is not considered sufficient. Naproxen/esomeprazole magnesium tablets have been compared with naproxen and celecoxib for these indications in head-to-head trials. This systematic literature review and network meta-analyses of data from randomized controlled trials was performed to compare naproxen/esomeprazole magnesium tablets with a number of additional relevant comparators. For this study, an original review examined MEDLINE®, Embase®, and the Cochrane Controlled Trials Register from database start to April 14, 2009. Using the same methodology, a review update was conducted to December 21, 2009. The systematic review and network analyses showed naproxen/esomeprazole magnesium tablets have an improved upper gastrointestinal tolerability profile (dyspepsia and gastric or gastroduodenal ulcers) over several active comparators (naproxen, ibuprofen, diclofenac, ketoprofen, etoricoxib, and fixed-dose diclofenac sodium plus misoprostol), and are equally effective as all active comparators in treating arthritic symptoms in patients with OA, RA, and AS. Naproxen/esomeprazole magnesium tablets are therefore a valuable option for treating arthritic symptoms in eligible patients with OA, RA, and AS.Keywords: non-steroidal anti-inflammatory drug, proton pump inhibitor, upper gastrointestinal tolerability, arthritis" @default.
• W2093486564 created "2016-06-24" @default.
• W2093486564 creator A5008103307 @default.
• W2093486564 creator A5013481282 @default.
• W2093486564 creator A5026705827 @default.
• W2093486564 creator A5068191835 @default.
• W2093486564 date "2013-02-01" @default.
• W2093486564 modified "2023-09-25" @default.
• W2093486564 title "Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses" @default.
• W2093486564 cites W104470354 @default.
• W2093486564 cites W10722190 @default.
• W2093486564 cites W1233216942 @default.
• W2093486564 cites W1480729244 @default.
• W2093486564 cites W1495262111 @default.
• W2093486564 cites W1558803517 @default.
• W2093486564 cites W1587112446 @default.
• W2093486564 cites W1592027262 @default.
• W2093486564 cites W1717393871 @default.
• W2093486564 cites W1832583951 @default.
• W2093486564 cites W1871126948 @default.
• W2093486564 cites W1953196589 @default.
• W2093486564 cites W1972361929 @default.
• W2093486564 cites W1972482928 @default.
• W2093486564 cites W1976852026 @default.
• W2093486564 cites W1977784731 @default.
• W2093486564 cites W1983104516 @default.
• W2093486564 cites W1985247069 @default.
• W2093486564 cites W1986215651 @default.
• W2093486564 cites W1988145586 @default.
• W2093486564 cites W1988751207 @default.
• W2093486564 cites W1989937199 @default.
• W2093486564 cites W1990824360 @default.
• W2093486564 cites W1992824602 @default.
• W2093486564 cites W1993738953 @default.
• W2093486564 cites W1995949289 @default.
• W2093486564 cites W199602180 @default.
• W2093486564 cites W1997642392 @default.
• W2093486564 cites W2003148060 @default.
• W2093486564 cites W2003877309 @default.
• W2093486564 cites W2004489626 @default.
• W2093486564 cites W2005947177 @default.
• W2093486564 cites W2006010099 @default.
• W2093486564 cites W2007061152 @default.
• W2093486564 cites W2009487578 @default.
• W2093486564 cites W2015173447 @default.
• W2093486564 cites W2020869366 @default.
• W2093486564 cites W2022179592 @default.
• W2093486564 cites W2026307408 @default.
• W2093486564 cites W2034013987 @default.
• W2093486564 cites W2034468337 @default.
• W2093486564 cites W2037640305 @default.
• W2093486564 cites W2038693293 @default.
• W2093486564 cites W2039149640 @default.
• W2093486564 cites W2040872866 @default.
• W2093486564 cites W2044859113 @default.
• W2093486564 cites W2047583950 @default.
• W2093486564 cites W2051356268 @default.
• W2093486564 cites W2053566831 @default.
• W2093486564 cites W2055841596 @default.
• W2093486564 cites W2056271161 @default.
• W2093486564 cites W2058308726 @default.
• W2093486564 cites W2060835590 @default.
• W2093486564 cites W2063529030 @default.
• W2093486564 cites W2067516611 @default.
• W2093486564 cites W2068161688 @default.
• W2093486564 cites W2068786447 @default.
• W2093486564 cites W2070600819 @default.
• W2093486564 cites W2074547887 @default.
• W2093486564 cites W2076113138 @default.
• W2093486564 cites W2078834004 @default.
• W2093486564 cites W2080195990 @default.
• W2093486564 cites W2083582055 @default.
• W2093486564 cites W2083781010 @default.
• W2093486564 cites W2084289720 @default.
• W2093486564 cites W2084863173 @default.
• W2093486564 cites W2085766555 @default.
• W2093486564 cites W2090007958 @default.
• W2093486564 cites W2101260486 @default.
• W2093486564 cites W2103796156 @default.
• W2093486564 cites W2104379105 @default.
• W2093486564 cites W2105341770 @default.
• W2093486564 cites W2107125692 @default.
• W2093486564 cites W2107178532 @default.
• W2093486564 cites W2107328434 @default.
• W2093486564 cites W2108345382 @default.
• W2093486564 cites W2109156797 @default.
• W2093486564 cites W2109399977 @default.
• W2093486564 cites W2109525472 @default.
• W2093486564 cites W2109601928 @default.
• W2093486564 cites W2113144077 @default.
• W2093486564 cites W2118203621 @default.
• W2093486564 cites W2120551915 @default.
• W2093486564 cites W2123366546 @default.
• W2093486564 cites W2123441868 @default.
• W2093486564 cites W2124678826 @default.
• W2093486564 cites W2125205359 @default.
• W2093486564 cites W2125435699 @default.
• W2093486564 cites W2127622911 @default.

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