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• W2093490717 startingPage "751" @default.
• W2093490717 abstract "These studies were undertaken to 1) determine whether repeated dosing with the peripheral benzodiazepine antagonist PK 11195 alters its ability to precipitate withdrawal abstinence in diazepam-dependent rats; 2) whether the administration of PK 11195 and the central benzodiazepine antagonist, flumazenil, 3 days apart to the same rat produces an ordering effect in the intensity of withdrawal abstinence; 3) whether there are gender differences in these effects. Age-matched male and female Sprague Dawley rats had capsules implanted weekly that contained approximately equal (mg/kg) doses of diazepam (120 and 90 mg, respectively) or empty capsules (controls). After 5 implants, the maximum precipitated withdrawal score (PAS(MAX)) induced by PK 11195 and/or flumazenil (10 mg/kg/IV, respectively) was measured. Repeated administration of PK 11195 (1x/day for 5 days) induced tolerance with regard to the intensity of the PAS(MAX) and with gender-related differences. When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex. The PK 11195- and flumazenil-induced PAS(MAX) was not changed by the order in which they were administered. There were gender differences in that females had a higher PAS(MAX) after flumazenil than after PK 11195 and vocalized more after all treatments than males." @default.
• W2093490717 created "2016-06-24" @default.
• W2093490717 creator A5000855403 @default.
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• W2093490717 creator A5049488705 @default.
• W2093490717 creator A5089695174 @default.
• W2093490717 date "2000-08-01" @default.
• W2093490717 modified "2023-09-26" @default.
• W2093490717 title "The Pharmacodynamics of PK 11195 in Diazepam-Dependent Male and Female Rats" @default.
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• W2093490717 doi "https://doi.org/10.1016/s0091-3057(00)00239-2" @default.
• W2093490717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10973513" @default.
• W2093490717 hasPublicationYear "2000" @default.
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