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• W2093497258 abstract "Natural killer (NK) T cells are a lymphocyte subset with a distinct surface phenotype, an invariant T cell receptor (TCR), and reactivity to CD1. Here we show that mouse NK T cells can recognize human CD1d as well as mouse CD1, and human NK T cells also recognize both CD1 homologues. The unprecedented degree of conservation of this T cell recognition system suggests that it is fundamentally important. Mouse or human CD1 molecules can present the glycolipid α-galactosylceramide (α-GalCer) to NK T cells from either species. Human T cells, preselected for invariant Vα24 TCR expression, uniformly recognize α-GalCer presented by either human CD1d or mouse CD1. In addition, culture of human peripheral blood cells with α-GalCer led to the dramatic expansion of NK T cells with an invariant (Vα24+) TCR and the release of large amounts of cytokines. Because invariant Vα14+ and Vα24+ NK T cells have been implicated both in the control of autoimmune disease and the response to tumors, our data suggest that α-GalCer could be a useful agent for modulating human immune responses by activation of the highly conserved NK T cell subset." @default.
• W2093497258 created "2016-06-24" @default.
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• W2093497258 date "1998-10-19" @default.
• W2093497258 modified "2023-10-11" @default.
• W2093497258 title "CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution" @default.
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• W2093497258 doi "https://doi.org/10.1084/jem.188.8.1521" @default.
• W2093497258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2213408" @default.
• W2093497258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9782129" @default.
• W2093497258 hasPublicationYear "1998" @default.
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