FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093497966> ?p ?o ?g. }

• W2093497966 endingPage "466" @default.
• W2093497966 startingPage "461" @default.
• W2093497966 abstract "Testicular germ cell tumours (TGCTs) are histologically heterogeneous neoplasms with variable malignant potential. Previously, we demonstrated frequent 3p allele loss in TGCTs, and recently we and others have shown that the 3p21.3 RASSF1A tumour suppressor gene (TSG) is frequently inactivated by promoter hypermethylation in a wide range of cancers including lung, breast, kidney and neuroblastoma. In order to investigate the role of epigenetic events in the pathogenesis of TGCTs, we analysed the promoter methylation status of RASSF1A and nine other genes that may be epigenetically inactivated in cancer (p16(INK4A), APC, MGMT, GSTP1, DAPK, CDH1, CDH13, RARbeta and FHIT) in 24 primary TGCTs (28 histologically distinct components). RASSF1A methylation was detected in four of 10 (40%) seminomas and 15 of 18 (83%) nonseminoma TGCT (NSTGCT) components (P=0.0346). None of the other nine candidate genes were methylated in seminomas, but MGMT (44%), APC (29%) and FHIT (29%) were frequently methylated in NSTGCTs. Furthermore, in two mixed germ cell tumours, the NSTGCT component for one demonstrated RASSF1A, APC and CDH13 promoter methylation, but the seminoma component was unmethylated for all genes analysed. In the second mixed germ cell tumour, the NSTGCT component was methylated for RASSF1A and MGMT, while the seminoma component was methylated only for RASSF1A. In all, 61% NSTGCT components but no seminoma samples demonstrated promoter methylation at two or more genes (P=0.0016). These findings are consistent with a multistep model for TGCT pathogenesis in which RASSF1A methylation occurs early in tumorigenesis and additional epigenetic events characterize progression from seminoma to NSTGCTs." @default.
• W2093497966 created "2016-06-24" @default.
• W2093497966 creator A5007968837 @default.
• W2093497966 creator A5024325273 @default.
• W2093497966 creator A5035346994 @default.
• W2093497966 creator A5069024377 @default.
• W2093497966 creator A5073770568 @default.
• W2093497966 creator A5090532039 @default.
• W2093497966 date "2003-01-22" @default.
• W2093497966 modified "2023-10-05" @default.
• W2093497966 title "Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumours" @default.
• W2093497966 cites W1504197144 @default.
• W2093497966 cites W1578821331 @default.
• W2093497966 cites W1605226225 @default.
• W2093497966 cites W1977370059 @default.
• W2093497966 cites W1978620346 @default.
• W2093497966 cites W1988950487 @default.
• W2093497966 cites W1994465394 @default.
• W2093497966 cites W2001258296 @default.
• W2093497966 cites W2016966142 @default.
• W2093497966 cites W2032053235 @default.
• W2093497966 cites W2050353342 @default.
• W2093497966 cites W2085964277 @default.
• W2093497966 cites W2086112120 @default.
• W2093497966 cites W2092243554 @default.
• W2093497966 cites W2092641158 @default.
• W2093497966 cites W2113459016 @default.
• W2093497966 cites W2128146359 @default.
• W2093497966 cites W2135325281 @default.
• W2093497966 cites W2150468415 @default.
• W2093497966 cites W2153354021 @default.
• W2093497966 cites W2314735012 @default.
• W2093497966 cites W2320541982 @default.
• W2093497966 doi "https://doi.org/10.1038/sj.onc.1206119" @default.
• W2093497966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12545168" @default.
• W2093497966 hasPublicationYear "2003" @default.
• W2093497966 type Work @default.
• W2093497966 sameAs 2093497966 @default.
• W2093497966 citedByCount "113" @default.
• W2093497966 countsByYear W20934979662012 @default.
• W2093497966 countsByYear W20934979662013 @default.
• W2093497966 countsByYear W20934979662014 @default.
• W2093497966 countsByYear W20934979662015 @default.
• W2093497966 countsByYear W20934979662016 @default.
• W2093497966 countsByYear W20934979662017 @default.
• W2093497966 countsByYear W20934979662018 @default.
• W2093497966 countsByYear W20934979662019 @default.
• W2093497966 countsByYear W20934979662020 @default.
• W2093497966 countsByYear W20934979662021 @default.
• W2093497966 countsByYear W20934979662022 @default.
• W2093497966 countsByYear W20934979662023 @default.
• W2093497966 crossrefType "journal-article" @default.
• W2093497966 hasAuthorship W2093497966A5007968837 @default.
• W2093497966 hasAuthorship W2093497966A5024325273 @default.
• W2093497966 hasAuthorship W2093497966A5035346994 @default.
• W2093497966 hasAuthorship W2093497966A5069024377 @default.
• W2093497966 hasAuthorship W2093497966A5073770568 @default.
• W2093497966 hasAuthorship W2093497966A5090532039 @default.
• W2093497966 hasBestOaLocation W20934979661 @default.
• W2093497966 hasConcept C104317684 @default.
• W2093497966 hasConcept C121608353 @default.
• W2093497966 hasConcept C150194340 @default.
• W2093497966 hasConcept C190727270 @default.
• W2093497966 hasConcept C2776694085 @default.
• W2093497966 hasConcept C2778074268 @default.
• W2093497966 hasConcept C2778264664 @default.
• W2093497966 hasConcept C2780646079 @default.
• W2093497966 hasConcept C33288867 @default.
• W2093497966 hasConcept C41091548 @default.
• W2093497966 hasConcept C502942594 @default.
• W2093497966 hasConcept C54355233 @default.
• W2093497966 hasConcept C555283112 @default.
• W2093497966 hasConcept C86803240 @default.
• W2093497966 hasConceptScore W2093497966C104317684 @default.
• W2093497966 hasConceptScore W2093497966C121608353 @default.
• W2093497966 hasConceptScore W2093497966C150194340 @default.
• W2093497966 hasConceptScore W2093497966C190727270 @default.
• W2093497966 hasConceptScore W2093497966C2776694085 @default.
• W2093497966 hasConceptScore W2093497966C2778074268 @default.
• W2093497966 hasConceptScore W2093497966C2778264664 @default.
• W2093497966 hasConceptScore W2093497966C2780646079 @default.
• W2093497966 hasConceptScore W2093497966C33288867 @default.
• W2093497966 hasConceptScore W2093497966C41091548 @default.
• W2093497966 hasConceptScore W2093497966C502942594 @default.
• W2093497966 hasConceptScore W2093497966C54355233 @default.
• W2093497966 hasConceptScore W2093497966C555283112 @default.
• W2093497966 hasConceptScore W2093497966C86803240 @default.
• W2093497966 hasIssue "3" @default.
• W2093497966 hasLocation W20934979661 @default.
• W2093497966 hasLocation W20934979662 @default.
• W2093497966 hasOpenAccess W2093497966 @default.
• W2093497966 hasPrimaryLocation W20934979661 @default.
• W2093497966 hasRelatedWork W1608616576 @default.
• W2093497966 hasRelatedWork W2024490794 @default.
• W2093497966 hasRelatedWork W2059108067 @default.
• W2093497966 hasRelatedWork W2068071476 @default.
• W2093497966 hasRelatedWork W2371467096 @default.
• W2093497966 hasRelatedWork W2393800602 @default.

• next