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• W2093508765 abstract "We present the structure of the human Aurora B kinase domain in complex with the C-terminal Aurora-binding region of human INCENP and the Aurora kinase inhibitor VX-680. The structure unexpectedly reveals a dimeric arrangement of the Aurora B:INCENP complex, which was confirmed to exist in solution by analytical ultracentrifugation. The dimerization involves a domain swap of the activation loop, resulting in a different conformation of the DFG motif as compared to that seen in other kinase complexes with VX-680. The binding of INCENP differs significantly from that seen in the Xenopus laevis Aurora B:INCENP complex currently used as a model for structure-based design for this important oncology target." @default.
• W2093508765 created "2016-06-24" @default.
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• W2093508765 date "2012-09-04" @default.
• W2093508765 modified "2023-09-27" @default.
• W2093508765 title "Crystal Structure of Human Aurora B in Complex with INCENP and VX-680" @default.
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• W2093508765 doi "https://doi.org/10.1021/jm3008954" @default.
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