Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093512107> ?p ?o ?g. }
- W2093512107 endingPage "258" @default.
- W2093512107 startingPage "252" @default.
- W2093512107 abstract "BACKGROUND/AIM Matrilysin is one of the matrix metalloproteinases that has a critical role in tumour invasion, and is often expressed in gastrointestinal cancers. The aim of this study was to examine the role of matrilysin in metastasis of human colorectal cancers. PATIENTS (SUBJECTS)/METHODS The relation between matrilysin expression and Dukes’s type was investigated immunohistochemically in 83 surgically resected colorectal cancers, including five with liver metastasis. Moreover, the effects of matrilysin on the in vivo invasive and metastatic potential of colon cancer cells transfected with matrilysin cDNA were examined after subcutaneous injection into SCID mice. RESULTS In 46% of primary and all of metastatic liver tumours, over 10% of cancer cells were stained positively for matrilysin. The expression of matrilysin correlated significantly with the presence of nodal or distant metastases (p<0.05). In addition, matrilysin transfectants formed invasive tumours and multiple liver metastases in SCID mice, without producing any significant difference in the subcutaneous tumour growth from mock transfectants. Casein zymography showed that the invading and metastasised tumours showed conspicuous matrilysin activity, which correlated with the number of metastatic lesions (p<0.001). CONCLUSIONS Matrilysin showed a correlation with metastasis in a cohort of 83 colorectal cancer patients and marked metastatic potentiation in human colorectal cancer xenografts, indicating that it may play a critical role in the metastatic pathway of colorectal cancers." @default.
- W2093512107 created "2016-06-24" @default.
- W2093512107 creator A5004215583 @default.
- W2093512107 creator A5045458943 @default.
- W2093512107 creator A5056029949 @default.
- W2093512107 creator A5064820734 @default.
- W2093512107 creator A5082981088 @default.
- W2093512107 creator A5084473736 @default.
- W2093512107 date "1999-08-01" @default.
- W2093512107 modified "2023-10-14" @default.
- W2093512107 title "Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers" @default.
- W2093512107 cites W1493755221 @default.
- W2093512107 cites W1521892157 @default.
- W2093512107 cites W1559400457 @default.
- W2093512107 cites W1598414191 @default.
- W2093512107 cites W1599093134 @default.
- W2093512107 cites W1676799983 @default.
- W2093512107 cites W1894541755 @default.
- W2093512107 cites W1964550340 @default.
- W2093512107 cites W1970839747 @default.
- W2093512107 cites W1971032614 @default.
- W2093512107 cites W1979390430 @default.
- W2093512107 cites W1982977732 @default.
- W2093512107 cites W1988683816 @default.
- W2093512107 cites W1990823585 @default.
- W2093512107 cites W1993280782 @default.
- W2093512107 cites W2001082958 @default.
- W2093512107 cites W2005912834 @default.
- W2093512107 cites W2013633208 @default.
- W2093512107 cites W2032483872 @default.
- W2093512107 cites W2046091872 @default.
- W2093512107 cites W2048172586 @default.
- W2093512107 cites W2049675777 @default.
- W2093512107 cites W2052372353 @default.
- W2093512107 cites W2068013043 @default.
- W2093512107 cites W2068712629 @default.
- W2093512107 cites W2087671339 @default.
- W2093512107 cites W2104193952 @default.
- W2093512107 cites W2104947013 @default.
- W2093512107 cites W2116477272 @default.
- W2093512107 cites W2123424871 @default.
- W2093512107 cites W2128635872 @default.
- W2093512107 cites W2140123544 @default.
- W2093512107 cites W2145310996 @default.
- W2093512107 cites W2158008521 @default.
- W2093512107 cites W2213958500 @default.
- W2093512107 cites W2444390998 @default.
- W2093512107 doi "https://doi.org/10.1136/gut.45.2.252" @default.
- W2093512107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1727600" @default.
- W2093512107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10403738" @default.
- W2093512107 hasPublicationYear "1999" @default.
- W2093512107 type Work @default.
- W2093512107 sameAs 2093512107 @default.
- W2093512107 citedByCount "212" @default.
- W2093512107 countsByYear W20935121072012 @default.
- W2093512107 countsByYear W20935121072013 @default.
- W2093512107 countsByYear W20935121072014 @default.
- W2093512107 countsByYear W20935121072015 @default.
- W2093512107 countsByYear W20935121072016 @default.
- W2093512107 countsByYear W20935121072017 @default.
- W2093512107 countsByYear W20935121072018 @default.
- W2093512107 countsByYear W20935121072019 @default.
- W2093512107 countsByYear W20935121072020 @default.
- W2093512107 countsByYear W20935121072021 @default.
- W2093512107 countsByYear W20935121072022 @default.
- W2093512107 countsByYear W20935121072023 @default.
- W2093512107 crossrefType "journal-article" @default.
- W2093512107 hasAuthorship W2093512107A5004215583 @default.
- W2093512107 hasAuthorship W2093512107A5045458943 @default.
- W2093512107 hasAuthorship W2093512107A5056029949 @default.
- W2093512107 hasAuthorship W2093512107A5064820734 @default.
- W2093512107 hasAuthorship W2093512107A5082981088 @default.
- W2093512107 hasAuthorship W2093512107A5084473736 @default.
- W2093512107 hasBestOaLocation W20935121071 @default.
- W2093512107 hasConcept C109523444 @default.
- W2093512107 hasConcept C121608353 @default.
- W2093512107 hasConcept C126322002 @default.
- W2093512107 hasConcept C142724271 @default.
- W2093512107 hasConcept C204232928 @default.
- W2093512107 hasConcept C2779013556 @default.
- W2093512107 hasConcept C2779939298 @default.
- W2093512107 hasConcept C502942594 @default.
- W2093512107 hasConcept C526805850 @default.
- W2093512107 hasConcept C71924100 @default.
- W2093512107 hasConceptScore W2093512107C109523444 @default.
- W2093512107 hasConceptScore W2093512107C121608353 @default.
- W2093512107 hasConceptScore W2093512107C126322002 @default.
- W2093512107 hasConceptScore W2093512107C142724271 @default.
- W2093512107 hasConceptScore W2093512107C204232928 @default.
- W2093512107 hasConceptScore W2093512107C2779013556 @default.
- W2093512107 hasConceptScore W2093512107C2779939298 @default.
- W2093512107 hasConceptScore W2093512107C502942594 @default.
- W2093512107 hasConceptScore W2093512107C526805850 @default.
- W2093512107 hasConceptScore W2093512107C71924100 @default.
- W2093512107 hasIssue "2" @default.
- W2093512107 hasLocation W20935121071 @default.
- W2093512107 hasLocation W20935121072 @default.
- W2093512107 hasLocation W20935121073 @default.