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- W2093513199 abstract "The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORL1. In the present study responses to intravenous administration of nociceptin were investigated in the systemic vascular bed of the rat. Nociceptin induced dose-related decreases in systemic arterial pressure when injected in doses of 1–30 nmolkg i.v. In tarns of relative vasodepressor activity, nociceptin was approximately 10-fold more potent than the nitric oxide donor, DEA/NO, and 10-fold less potent than adrenomedullin. The duration of the vasodepressor response to nociceptin was shorter than adrenomedullin but longer than DEA/NO. These results show that nociceptin has significant vasodepressor activity in the rat." @default.
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- W2093513199 date "1997-03-01" @default.
- W2093513199 modified "2023-09-27" @default.
- W2093513199 title "Nociceptin, an endogenous ligand for the ORL1 receptor, has novel hypotensive activity in the rat" @default.
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- W2093513199 doi "https://doi.org/10.1016/s0024-3205(97)00087-8" @default.
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