FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093517943> ?p ?o ?g. }

• W2093517943 endingPage "185" @default.
• W2093517943 startingPage "179" @default.
• W2093517943 abstract "Thrombus formation on a disrupted atherosclerotic plaque is the main pathogenetic mechanism for the acute coronary syndromes of myocardial infarction and unstable angina. Myocardial infarction results from an acute total occlusion of the artery, while unstable angina is secondary in most cases to mural thrombus formation. Thrombus formation has also been implicated in chronic atherosclerotic disease progression, and in restenosis following coronary angioplasty. Therapeutic measures to treat thrombus rely on the ability of drugs either to prevent thrombus extension, to dissolve its fibrin component, or to prevent further platelet aggregation.Following arterial vessel wall injury, platelets adhere to the subendothelial collagen. Glycoprotein Ib on the platelet membrane is the primary receptor for this single layer of platelets, and it binds von Willebrand factor as its extracellular ligand. Platelet aggregation involves activation of several different pathways leading to exposure of the glycoprotein IIb/IIIa receptor on the platelet. These receptors bind either fibrinogen or von Willebrand factor, leading to platelet‐ platelet interaction and the formation of a white platelet thrombus. The luminal component of thrombus is a mixture of platelets and fibrin. The occlusive tail of the thrombus is composed of red blood cells and fibrin (red thrombus).Both plaque disruption and erosion of a plaque involve the presence of an inflammatory process at the site of thrombus formation. This inflammatory process consists primarily of activated macrophages and T lymphocytes.Thrombus formation depends on at least three factors: (i) the depth of vessel wall injury and the thrombogenicity of the exposed plaque; (ii) the prothrombotic state; and (iii) haemodynamic factors that promote vasoconstriction and stasis of blood flow.Traditionally, plaque rupture has been considered to result mainly from the physical pressure exerted upon the plaque surface. The plaque's vulnerability to rupture depends upon the size and consistency of its atheromatous core. Davies …" @default.
• W2093517943 created "2016-06-24" @default.
• W2093517943 creator A5027554899 @default.
• W2093517943 date "2001-04-01" @default.
• W2093517943 modified "2023-09-24" @default.
• W2093517943 title "Current trends in the management of thromboembolic events" @default.
• W2093517943 cites W1507312029 @default.
• W2093517943 cites W1581187193 @default.
• W2093517943 cites W1581557633 @default.
• W2093517943 cites W1589999021 @default.
• W2093517943 cites W187302396 @default.
• W2093517943 cites W1965958910 @default.
• W2093517943 cites W1970472124 @default.
• W2093517943 cites W198418484 @default.
• W2093517943 cites W1984643311 @default.
• W2093517943 cites W1990107586 @default.
• W2093517943 cites W1996102904 @default.
• W2093517943 cites W2007798223 @default.
• W2093517943 cites W2026856116 @default.
• W2093517943 cites W2032105970 @default.
• W2093517943 cites W2033724005 @default.
• W2093517943 cites W2034193633 @default.
• W2093517943 cites W2050802944 @default.
• W2093517943 cites W2057711799 @default.
• W2093517943 cites W2067397226 @default.
• W2093517943 cites W2074616023 @default.
• W2093517943 cites W2082372484 @default.
• W2093517943 cites W2082589265 @default.
• W2093517943 cites W2087098935 @default.
• W2093517943 cites W2092043066 @default.
• W2093517943 cites W2106837301 @default.
• W2093517943 cites W2118015645 @default.
• W2093517943 cites W2142307051 @default.
• W2093517943 cites W2145710740 @default.
• W2093517943 cites W2149599987 @default.
• W2093517943 cites W2164807534 @default.
• W2093517943 cites W22019582 @default.
• W2093517943 cites W2312652910 @default.
• W2093517943 cites W2315575691 @default.
• W2093517943 cites W2316460201 @default.
• W2093517943 cites W2319326268 @default.
• W2093517943 cites W2325460018 @default.
• W2093517943 cites W2329311416 @default.
• W2093517943 cites W2336672206 @default.
• W2093517943 cites W2338618131 @default.
• W2093517943 cites W2340468754 @default.
• W2093517943 cites W2342200163 @default.
• W2093517943 cites W2409445331 @default.
• W2093517943 cites W2416929543 @default.
• W2093517943 cites W246989876 @default.
• W2093517943 cites W56239716 @default.
• W2093517943 cites W2036974917 @default.
• W2093517943 cites W2054940625 @default.
• W2093517943 cites W2088411381 @default.
• W2093517943 doi "https://doi.org/10.1093/qjmed/94.4.179" @default.
• W2093517943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11294960" @default.
• W2093517943 hasPublicationYear "2001" @default.
• W2093517943 type Work @default.
• W2093517943 sameAs 2093517943 @default.
• W2093517943 citedByCount "3" @default.
• W2093517943 countsByYear W20935179432018 @default.
• W2093517943 crossrefType "journal-article" @default.
• W2093517943 hasAuthorship W2093517943A5027554899 @default.
• W2093517943 hasBestOaLocation W20935179431 @default.
• W2093517943 hasConcept C111368507 @default.
• W2093517943 hasConcept C127313418 @default.
• W2093517943 hasConcept C144133560 @default.
• W2093517943 hasConcept C148043351 @default.
• W2093517943 hasConceptScore W2093517943C111368507 @default.
• W2093517943 hasConceptScore W2093517943C127313418 @default.
• W2093517943 hasConceptScore W2093517943C144133560 @default.
• W2093517943 hasConceptScore W2093517943C148043351 @default.
• W2093517943 hasIssue "4" @default.
• W2093517943 hasLocation W20935179431 @default.
• W2093517943 hasLocation W20935179432 @default.
• W2093517943 hasOpenAccess W2093517943 @default.
• W2093517943 hasPrimaryLocation W20935179431 @default.
• W2093517943 hasRelatedWork W1982412832 @default.
• W2093517943 hasRelatedWork W2006863447 @default.
• W2093517943 hasRelatedWork W2014021078 @default.
• W2093517943 hasRelatedWork W2031756445 @default.
• W2093517943 hasRelatedWork W2114356148 @default.
• W2093517943 hasRelatedWork W2351224547 @default.
• W2093517943 hasRelatedWork W2358945257 @default.
• W2093517943 hasRelatedWork W2384573129 @default.
• W2093517943 hasRelatedWork W4244464241 @default.
• W2093517943 hasRelatedWork W4318692582 @default.
• W2093517943 hasVolume "94" @default.
• W2093517943 isParatext "false" @default.
• W2093517943 isRetracted "false" @default.
• W2093517943 magId "2093517943" @default.
• W2093517943 workType "article" @default.