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- W2093518411 endingPage "1318" @default.
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- W2093518411 abstract "Introduction: Basal cell carcinoma (BCC) is the most frequent cancer with increasing incidence over the last decades. Standard of care is surgical excision, upon which complete tumour clearance is achieved in most cases. However, a small subgroup of patients will have remnants of disease post-excision and require further treatment options. Over 90% of all BCCs carry a mutation in PTCH 1 or SMO, two conducting proteins of the Hedgehog pathway (Hh). Therefore, inhibition of the Hh pathway is a promising option for systemic first-line therapy. Vismodegib was the first developed of these small molecules, which was approved by the FDA in January 2012. Areas covered: The authors review current treatment modalities for BCC and discuss current developments in pharmacological therapy. The current literature including meta-analyses, the Cochrane database and registered as well as completed randomized controlled trials. Expert opinion: Hh inhibitors are a new promising treatment option for patients with advanced or metastatic BCC. Phase I and II clinical trials with the Hh inhibitor, vismodegib, showed a significant reduction in tumour size and appearance of new tumours with relatively good tolerability. Nevertheless, further investigation on new molecules and the effectiveness of an intermittent dosing regimen is necessary." @default.
- W2093518411 created "2016-06-24" @default.
- W2093518411 creator A5031190166 @default.
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- W2093518411 creator A5034017443 @default.
- W2093518411 creator A5039525756 @default.
- W2093518411 creator A5089297467 @default.
- W2093518411 date "2013-05-08" @default.
- W2093518411 modified "2023-09-23" @default.
- W2093518411 title "Basal cell carcinoma: a paradigm for targeted therapies" @default.
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