FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093522076> ?p ?o ?g. }

• W2093522076 abstract "Gene transfer of glial cell line-derived neurotrophic factor (GDNF) in rodent models of Parkinson's disease (PD) has been shown to protect against neurodegeneration either prior to or immediately after neurotoxin-induced lesions; however, the nigrostriatal pathway was largely intact when gene delivery was completed in these models, which may not accurately reflect the clinical situation encountered with Parkinson's patients. In this study, replication-incompetent adenoviral vectors encoding the rat GDNF gene were administered into the striatum 4 weeks following 6-hydroxydopamine (6-OHDA) injection in the unilateral striatum, more closely resembling fully developed PD. Apomorphine-induced rotational behavior testing was performed every week following 6-OHDA injection. At the 10th week after gene transfer, the striatal dopamine concentrations were measured by HPLC with an electrochemical detector and the number of tyrosine hydroxylase (TH)-positive dopamine neurons in the substantia nigra (SN) was determined by immunohistochemistry. Injection of 6-OHDA into the striatum produced stable increases in rotation, which reached a plateau between 4 and 5 weeks post-injection. The number of TH-positive neuron in the SN and dopamine levels in the striatum was significantly lower in the 6-OHDA group compared to the normal group. Gene transfer of GDNF, but not beta-galactosidase, significantly increased the number of TH-positive neurons and dopamine levels, with a subsequent behavioral recovery between 5 and 10 weeks following GDNF transduction. These findings demonstrate that adenovirus-mediated gene transfer of GDNF is efficacious even in the late stages of 6-OHDA-induced PD rats. They also provide further evidence on the effectiveness of GDNF-based gene therapy for experimental Parkinson's disease." @default.
• W2093522076 created "2016-06-24" @default.
• W2093522076 creator A5000755272 @default.
• W2093522076 creator A5006227056 @default.
• W2093522076 creator A5008792037 @default.
• W2093522076 creator A5010958225 @default.
• W2093522076 creator A5019376005 @default.
• W2093522076 creator A5022756228 @default.
• W2093522076 creator A5054897932 @default.
• W2093522076 creator A5088560950 @default.
• W2093522076 date "2005-03-01" @default.
• W2093522076 modified "2023-09-26" @default.
• W2093522076 title "Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson's disease" @default.
• W2093522076 cites W153379164 @default.
• W2093522076 cites W1970416276 @default.
• W2093522076 cites W1975637203 @default.
• W2093522076 cites W1986811009 @default.
• W2093522076 cites W1988463041 @default.
• W2093522076 cites W1991574243 @default.
• W2093522076 cites W2003548745 @default.
• W2093522076 cites W2010143122 @default.
• W2093522076 cites W2022744505 @default.
• W2093522076 cites W2026856348 @default.
• W2093522076 cites W2030550013 @default.
• W2093522076 cites W2041709722 @default.
• W2093522076 cites W2043458930 @default.
• W2093522076 cites W2056594935 @default.
• W2093522076 cites W2057159662 @default.
• W2093522076 cites W2061219878 @default.
• W2093522076 cites W2061744249 @default.
• W2093522076 cites W2062598259 @default.
• W2093522076 cites W2065000444 @default.
• W2093522076 cites W2074432223 @default.
• W2093522076 cites W2078526445 @default.
• W2093522076 cites W2079935484 @default.
• W2093522076 cites W2088827109 @default.
• W2093522076 cites W2108724455 @default.
• W2093522076 cites W2115640450 @default.
• W2093522076 cites W2133781582 @default.
• W2093522076 cites W2139661803 @default.
• W2093522076 cites W2140993633 @default.
• W2093522076 cites W2150857721 @default.
• W2093522076 cites W2158649743 @default.
• W2093522076 cites W2177094286 @default.
• W2093522076 cites W4232045797 @default.
• W2093522076 doi "https://doi.org/10.1016/j.molbrainres.2004.06.029" @default.
• W2093522076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15790539" @default.
• W2093522076 hasPublicationYear "2005" @default.
• W2093522076 type Work @default.
• W2093522076 sameAs 2093522076 @default.
• W2093522076 citedByCount "45" @default.
• W2093522076 countsByYear W20935220762012 @default.
• W2093522076 countsByYear W20935220762013 @default.
• W2093522076 countsByYear W20935220762014 @default.
• W2093522076 countsByYear W20935220762017 @default.
• W2093522076 countsByYear W20935220762018 @default.
• W2093522076 countsByYear W20935220762019 @default.
• W2093522076 countsByYear W20935220762020 @default.
• W2093522076 countsByYear W20935220762021 @default.
• W2093522076 crossrefType "journal-article" @default.
• W2093522076 hasAuthorship W2093522076A5000755272 @default.
• W2093522076 hasAuthorship W2093522076A5006227056 @default.
• W2093522076 hasAuthorship W2093522076A5008792037 @default.
• W2093522076 hasAuthorship W2093522076A5010958225 @default.
• W2093522076 hasAuthorship W2093522076A5019376005 @default.
• W2093522076 hasAuthorship W2093522076A5022756228 @default.
• W2093522076 hasAuthorship W2093522076A5054897932 @default.
• W2093522076 hasAuthorship W2093522076A5088560950 @default.
• W2093522076 hasConcept C126322002 @default.
• W2093522076 hasConcept C134018914 @default.
• W2093522076 hasConcept C137183658 @default.
• W2093522076 hasConcept C159167319 @default.
• W2093522076 hasConcept C160539049 @default.
• W2093522076 hasConcept C169760540 @default.
• W2093522076 hasConcept C170493617 @default.
• W2093522076 hasConcept C185856081 @default.
• W2093522076 hasConcept C2776925932 @default.
• W2093522076 hasConcept C2778674702 @default.
• W2093522076 hasConcept C2779134260 @default.
• W2093522076 hasConcept C2779734285 @default.
• W2093522076 hasConcept C2780062018 @default.
• W2093522076 hasConcept C2780358027 @default.
• W2093522076 hasConcept C2780938664 @default.
• W2093522076 hasConcept C513476851 @default.
• W2093522076 hasConcept C71924100 @default.
• W2093522076 hasConcept C86803240 @default.
• W2093522076 hasConceptScore W2093522076C126322002 @default.
• W2093522076 hasConceptScore W2093522076C134018914 @default.
• W2093522076 hasConceptScore W2093522076C137183658 @default.
• W2093522076 hasConceptScore W2093522076C159167319 @default.
• W2093522076 hasConceptScore W2093522076C160539049 @default.
• W2093522076 hasConceptScore W2093522076C169760540 @default.
• W2093522076 hasConceptScore W2093522076C170493617 @default.
• W2093522076 hasConceptScore W2093522076C185856081 @default.
• W2093522076 hasConceptScore W2093522076C2776925932 @default.
• W2093522076 hasConceptScore W2093522076C2778674702 @default.
• W2093522076 hasConceptScore W2093522076C2779134260 @default.
• W2093522076 hasConceptScore W2093522076C2779734285 @default.
• W2093522076 hasConceptScore W2093522076C2780062018 @default.
• W2093522076 hasConceptScore W2093522076C2780358027 @default.

• next