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- W2093522170 abstract "Male rats were treated with single oral doses of 800 or 1200 mg/kg of dl-ethionine, with and without additional subcutaneous injections of cycloheximide (CHM), and were killed after 24 and 48 hr. Other rats were given oral dl-ethionine at the level of 8000 mg/kg and killed 24 or 48 hr or 10 days after treatment. It is known that this dose does not produce the early histopathological changes which result from treatment with the lower doses and it has therefore been termed “autoprotective,” owing to the apparent similarity of its effects to those of combined treatment with CHM and dl-ethionine. The hepatic tissues were examined by electron microscopy. dl-Ethionine induced a characteristic lesion involving perinuclear glycogen pooling, with peripheral displacement of the cytoplasmic organelles, and rarefaction of the glycogen. This was prevented by CHM which, however, greatly enhanced changes in the granular endoplasmic reticulum and Golgi apparatus. Autoprotective doses of dl-ethionine also failed to induce this lesion but resulted in marked changes in the endoplasmic reticulum. By 10 days after 8000 mg/kg of dl-ethionine, delayed damage occurred, apparently identical to that produced within 24 hr by lower doses. Because of the similar fine structural effects induced by CHM protection and autoprotection, it is concluded that both may have a common mechanistic basis, which may be related to inhibition of protein synthesis in the hepatocyte." @default.
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- W2093522170 date "1976-03-01" @default.
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- W2093522170 title "Modification of toxic liver injury in the rat. III. Fine structure of hepatocytes during cycloheximide protection and autoprotection in acute ethionine intoxication" @default.
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- W2093522170 doi "https://doi.org/10.1016/0041-008x(76)90065-x" @default.
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