FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093523311> ?p ?o ?g. }

• W2093523311 endingPage "75" @default.
• W2093523311 startingPage "53" @default.
• W2093523311 abstract "To identify, with certainty, the primary genotoxic effects of ethanol, condidia from diploid strains of Aspergillus nidulans were treated during early germination with ethyl alcohol, and all the resulting segregants from large samples were analysed in detail. Results were identical whether technical grade (95%), or highly purified ‘absolute’, alcohol was diluted to obtain the effective low levels of ethanol (3–6%). This makes it unlikely that trace contaminants, rather than ethanol itself, caused the observed induced segregation. At the most effective concentrations survival was about 50%, but over half of the colonies were abnormal and showed sectoring phenotypes. Higher concentrations were too inhibitory for growth. In practically all cases, when ‘abnormals’ were replated, aneuploids of various types were recovered. Most aneuploids were hyperdiploid, including a fraction of simple trisomics, and some were even polyploid types. All showed chromosomal-type segregation in diploid sectors, often segregating for genetic markers of many different chromosomes. Mitotic crossing-over was slightly increased, but probably not induced, since an equally high spontaneous frequency was observed among replated aneuploid types. To eliminate conclusively the possibility that chromosome breakage was the primary effect of ethanol, which might indirectly produce aneuploid-like types, haploid conidia were also treated. Up to 8% abnormals, mainly hyperhaploids, were obtained (at about 20–50% survival). When diploid and haploid strains were treated identically with ethanol in liquid media after a few hours of pregermination, frequencies of abnormals were similar for short treatments, but higher in diploid strains for longer ones (10–20% aneuploids). The abnormal colonies from the haploid strain were replated and visually identified: about 23 were typical n + 1 hyperhaploids, and most others were n + 2 or 3 or more, including a few 2n + 1 trisomics. It is concluded that as a primary effect, alcohol interferes with, and probably arrests, mitotic segregation, and causes chromosome missegregation and nondisjunction. In most cases, the resulting nuclei contain increased numbers of chromosomes and show high frequencies of chromosome loss." @default.
• W2093523311 created "2016-06-24" @default.
• W2093523311 creator A5061381194 @default.
• W2093523311 date "1984-01-01" @default.
• W2093523311 modified "2023-09-24" @default.
• W2093523311 title "Disruptive effects of ethyl alcohol on mitotic chromosome segregation in diploid and haploid strains of Aspergillus nidulans" @default.
• W2093523311 cites W17439892 @default.
• W2093523311 cites W1850334395 @default.
• W2093523311 cites W1941502008 @default.
• W2093523311 cites W1979838808 @default.
• W2093523311 cites W1982566878 @default.
• W2093523311 cites W1987062717 @default.
• W2093523311 cites W1990703358 @default.
• W2093523311 cites W1992237040 @default.
• W2093523311 cites W2000266801 @default.
• W2093523311 cites W2000444283 @default.
• W2093523311 cites W2010139512 @default.
• W2093523311 cites W2029714773 @default.
• W2093523311 cites W2039829159 @default.
• W2093523311 cites W2040192940 @default.
• W2093523311 cites W2054047398 @default.
• W2093523311 cites W2056127780 @default.
• W2093523311 cites W2067986257 @default.
• W2093523311 cites W2080602888 @default.
• W2093523311 cites W2083006044 @default.
• W2093523311 cites W2087074707 @default.
• W2093523311 cites W2153751911 @default.
• W2093523311 cites W2289985360 @default.
• W2093523311 cites W2297147980 @default.
• W2093523311 cites W2416976360 @default.
• W2093523311 cites W32993074 @default.
• W2093523311 cites W74173866 @default.
• W2093523311 doi "https://doi.org/10.1016/0165-1218(84)90148-4" @default.
• W2093523311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6363912" @default.
• W2093523311 hasPublicationYear "1984" @default.
• W2093523311 type Work @default.
• W2093523311 sameAs 2093523311 @default.
• W2093523311 citedByCount "23" @default.
• W2093523311 countsByYear W20935233112014 @default.
• W2093523311 crossrefType "journal-article" @default.
• W2093523311 hasAuthorship W2093523311A5061381194 @default.
• W2093523311 hasConcept C104317684 @default.
• W2093523311 hasConcept C143065580 @default.
• W2093523311 hasConcept C143191323 @default.
• W2093523311 hasConcept C2776626444 @default.
• W2093523311 hasConcept C2776923806 @default.
• W2093523311 hasConcept C2779672484 @default.
• W2093523311 hasConcept C2780161600 @default.
• W2093523311 hasConcept C30481170 @default.
• W2093523311 hasConcept C53226629 @default.
• W2093523311 hasConcept C54355233 @default.
• W2093523311 hasConcept C55493867 @default.
• W2093523311 hasConcept C86803240 @default.
• W2093523311 hasConcept C93304396 @default.
• W2093523311 hasConceptScore W2093523311C104317684 @default.
• W2093523311 hasConceptScore W2093523311C143065580 @default.
• W2093523311 hasConceptScore W2093523311C143191323 @default.
• W2093523311 hasConceptScore W2093523311C2776626444 @default.
• W2093523311 hasConceptScore W2093523311C2776923806 @default.
• W2093523311 hasConceptScore W2093523311C2779672484 @default.
• W2093523311 hasConceptScore W2093523311C2780161600 @default.
• W2093523311 hasConceptScore W2093523311C30481170 @default.
• W2093523311 hasConceptScore W2093523311C53226629 @default.
• W2093523311 hasConceptScore W2093523311C54355233 @default.
• W2093523311 hasConceptScore W2093523311C55493867 @default.
• W2093523311 hasConceptScore W2093523311C86803240 @default.
• W2093523311 hasConceptScore W2093523311C93304396 @default.
• W2093523311 hasIssue "1" @default.
• W2093523311 hasLocation W20935233111 @default.
• W2093523311 hasLocation W20935233112 @default.
• W2093523311 hasOpenAccess W2093523311 @default.
• W2093523311 hasPrimaryLocation W20935233111 @default.
• W2093523311 hasRelatedWork W1536101346 @default.
• W2093523311 hasRelatedWork W2026189426 @default.
• W2093523311 hasRelatedWork W2027802390 @default.
• W2093523311 hasRelatedWork W2038816622 @default.
• W2093523311 hasRelatedWork W2051656085 @default.
• W2093523311 hasRelatedWork W2082056843 @default.
• W2093523311 hasRelatedWork W2089376994 @default.
• W2093523311 hasRelatedWork W2136184215 @default.
• W2093523311 hasRelatedWork W2136879448 @default.
• W2093523311 hasRelatedWork W3112352375 @default.
• W2093523311 hasVolume "135" @default.
• W2093523311 isParatext "false" @default.
• W2093523311 isRetracted "false" @default.
• W2093523311 magId "2093523311" @default.
• W2093523311 workType "article" @default.