FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093524719> ?p ?o ?g. }

• W2093524719 endingPage "1145" @default.
• W2093524719 startingPage "1137" @default.
• W2093524719 abstract "The dopaminergic neurons of the ventral tegmental area (DA VTA neurons) have been implicated in the reinforcing properties of drugs of abuse, including ethanol (ethyl alcohol). Ethanol increases the spontaneous firing frequency of DA VTA neurons in vitro, in both brain slices and acutely dissociated neurons, and also in vivo. In many systems, longer n-alkyl alcohols have a more potent effect than ethanol, and the potency is a function of the number of carbons in the alkyl chain. We studied n-alcohols of chain length 1 (methanol) to 5 (pentanol) on the firing rate of DA VTA neurons in brain slice preparations. All of the alcohols studied produced increases in the spontaneous firing frequency in DA VTA neurons; as the chain length increased, lower concentrations of the alcohols were needed to produce the same percentage increase in firing. With very high concentrations of all the alcohols except methanol, we observed apparent depolarization block of firing. In addition, trichloroethanol (TCE), the active metabolite of chloral hydrate, increased the firing frequency of DA VTA neurons, and the EC(40) (concentration to produce a 40% increase in firing rate) of TCE was below that of ethanol. These studies indicate that excitation of VTA dopamine neurons by n-alcohols is related to the chain length of the carbons. This is likely to be a characteristic of the ethanol-sensitive element of DA VTA neurons and may be useful in identifying the element of the membrane that is responsible for ethanol-induced excitation." @default.
• W2093524719 created "2016-06-24" @default.
• W2093524719 creator A5002678633 @default.
• W2093524719 creator A5004745968 @default.
• W2093524719 creator A5007946396 @default.
• W2093524719 creator A5048640752 @default.
• W2093524719 creator A5082543371 @default.
• W2093524719 creator A5086756645 @default.
• W2093524719 date "2006-06-01" @default.
• W2093524719 modified "2023-09-23" @default.
• W2093524719 title "The Effects of Long Chain-Length <i>n</i>-Alcohols on the Firing Frequency of Dopaminergic Neurons of the Ventral Tegmental Area" @default.
• W2093524719 cites W1537202898 @default.
• W2093524719 cites W1555529117 @default.
• W2093524719 cites W1561818412 @default.
• W2093524719 cites W1630214027 @default.
• W2093524719 cites W1764026126 @default.
• W2093524719 cites W1965971750 @default.
• W2093524719 cites W1976454573 @default.
• W2093524719 cites W1981209032 @default.
• W2093524719 cites W1983412442 @default.
• W2093524719 cites W1993046534 @default.
• W2093524719 cites W2011731093 @default.
• W2093524719 cites W2015085616 @default.
• W2093524719 cites W2018162918 @default.
• W2093524719 cites W2027256318 @default.
• W2093524719 cites W2036880132 @default.
• W2093524719 cites W2039604720 @default.
• W2093524719 cites W2047403052 @default.
• W2093524719 cites W2054982167 @default.
• W2093524719 cites W2061874238 @default.
• W2093524719 cites W2068949066 @default.
• W2093524719 cites W2071280486 @default.
• W2093524719 cites W2072588605 @default.
• W2093524719 cites W2077077098 @default.
• W2093524719 cites W2078206616 @default.
• W2093524719 cites W2079037879 @default.
• W2093524719 cites W2090533972 @default.
• W2093524719 cites W2117333544 @default.
• W2093524719 cites W2122500528 @default.
• W2093524719 cites W2156823117 @default.
• W2093524719 cites W2165398609 @default.
• W2093524719 cites W4241753210 @default.
• W2093524719 cites W87854755 @default.
• W2093524719 doi "https://doi.org/10.1124/jpet.106.105148" @default.
• W2093524719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16740620" @default.
• W2093524719 hasPublicationYear "2006" @default.
• W2093524719 type Work @default.
• W2093524719 sameAs 2093524719 @default.
• W2093524719 citedByCount "14" @default.
• W2093524719 countsByYear W20935247192014 @default.
• W2093524719 countsByYear W20935247192015 @default.
• W2093524719 countsByYear W20935247192019 @default.
• W2093524719 countsByYear W20935247192020 @default.
• W2093524719 countsByYear W20935247192021 @default.
• W2093524719 countsByYear W20935247192022 @default.
• W2093524719 crossrefType "journal-article" @default.
• W2093524719 hasAuthorship W2093524719A5002678633 @default.
• W2093524719 hasAuthorship W2093524719A5004745968 @default.
• W2093524719 hasAuthorship W2093524719A5007946396 @default.
• W2093524719 hasAuthorship W2093524719A5048640752 @default.
• W2093524719 hasAuthorship W2093524719A5082543371 @default.
• W2093524719 hasAuthorship W2093524719A5086756645 @default.
• W2093524719 hasConcept C12554922 @default.
• W2093524719 hasConcept C137183658 @default.
• W2093524719 hasConcept C169760540 @default.
• W2093524719 hasConcept C185592680 @default.
• W2093524719 hasConcept C2777612814 @default.
• W2093524719 hasConcept C2780161600 @default.
• W2093524719 hasConcept C2780948874 @default.
• W2093524719 hasConcept C2781066024 @default.
• W2093524719 hasConcept C4141045 @default.
• W2093524719 hasConcept C513476851 @default.
• W2093524719 hasConcept C55493867 @default.
• W2093524719 hasConcept C86803240 @default.
• W2093524719 hasConcept C98274493 @default.
• W2093524719 hasConceptScore W2093524719C12554922 @default.
• W2093524719 hasConceptScore W2093524719C137183658 @default.
• W2093524719 hasConceptScore W2093524719C169760540 @default.
• W2093524719 hasConceptScore W2093524719C185592680 @default.
• W2093524719 hasConceptScore W2093524719C2777612814 @default.
• W2093524719 hasConceptScore W2093524719C2780161600 @default.
• W2093524719 hasConceptScore W2093524719C2780948874 @default.
• W2093524719 hasConceptScore W2093524719C2781066024 @default.
• W2093524719 hasConceptScore W2093524719C4141045 @default.
• W2093524719 hasConceptScore W2093524719C513476851 @default.
• W2093524719 hasConceptScore W2093524719C55493867 @default.
• W2093524719 hasConceptScore W2093524719C86803240 @default.
• W2093524719 hasConceptScore W2093524719C98274493 @default.
• W2093524719 hasIssue "3" @default.
• W2093524719 hasLocation W20935247191 @default.
• W2093524719 hasLocation W20935247192 @default.
• W2093524719 hasOpenAccess W2093524719 @default.
• W2093524719 hasPrimaryLocation W20935247191 @default.
• W2093524719 hasRelatedWork W1972796309 @default.
• W2093524719 hasRelatedWork W2009516385 @default.
• W2093524719 hasRelatedWork W2032984859 @default.
• W2093524719 hasRelatedWork W2044479377 @default.
• W2093524719 hasRelatedWork W2067572720 @default.

• next