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- W2093526199 abstract "2-chloro[3H]adenosine, a stable analog of adenosine, was used to investigate the presence of adenosine receptors in rat hippocampal membranes that may mediate the depressant effects of adenosine on synaptic transmission in this tissue. Equilibrium binding studies reveal the presence of a previously undescribed class of receptors with a KD of 4.7 uM and a Bmax of 130 pmol/mg of protein. Binding is sensitive to alkylxanthines and to a number of adenosine-related compounds. The pharmacological properties of this binding site are distinct from those of the A1 and A2 adenosine receptors associated with adenylate cyclase. The results suggest that this adenosine binding site is a novel central purinergic receptor through which adenosine may regulate hippocampal excitability." @default.
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- W2093526199 date "1965-03-01" @default.
- W2093526199 modified "2023-10-10" @default.
- W2093526199 title "Regulation of adenylate deaminase by adenosine triphosphate" @default.
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- W2093526199 doi "https://doi.org/10.1016/0005-2787(65)90575-7" @default.
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