Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093527800> ?p ?o ?g. }
- W2093527800 endingPage "561" @default.
- W2093527800 startingPage "553" @default.
- W2093527800 abstract "The Apg12 system is one of the ubiquitin-like protein conjugation systems conserved in eukaryotes. It was first discovered in yeast during systematic analyses of the apg mutants defective in autophagy, which is the intracellular bulk degradation system. Covalent attachment of Apg12–Apg5 is essential for autophagy. Enzymes catalyzing this conjugation reaction were also identified based on the apg mutant analyses. These are Apg7 and Apg10, corresponding to E1 and E2 enzymes, respectively. Studies using mammalian cells further revealed the function of the Apg12 system. The Apg12–Apg5 conjugate localizes to elongating autophagic isolation membranes. Apg12 conjugation of Apg5 is required for elongation of the isolation membrane to form a complete spherical autophagosome. Discovery of the Apg12 system has facilitated our understanding of the molecular mechanism of autophagosome formation." @default.
- W2093527800 created "2016-06-24" @default.
- W2093527800 creator A5038112377 @default.
- W2093527800 creator A5056765809 @default.
- W2093527800 creator A5070039006 @default.
- W2093527800 date "2003-05-01" @default.
- W2093527800 modified "2023-10-18" @default.
- W2093527800 title "Role of the Apg12 conjugation system in mammalian autophagy" @default.
- W2093527800 cites W1487317148 @default.
- W2093527800 cites W1495683398 @default.
- W2093527800 cites W1503849410 @default.
- W2093527800 cites W1526993239 @default.
- W2093527800 cites W1531145879 @default.
- W2093527800 cites W1555054913 @default.
- W2093527800 cites W1570925259 @default.
- W2093527800 cites W1643149493 @default.
- W2093527800 cites W1666755687 @default.
- W2093527800 cites W1784425676 @default.
- W2093527800 cites W1834837759 @default.
- W2093527800 cites W1964052965 @default.
- W2093527800 cites W1967085696 @default.
- W2093527800 cites W1969416716 @default.
- W2093527800 cites W1977767269 @default.
- W2093527800 cites W1981358316 @default.
- W2093527800 cites W1985706328 @default.
- W2093527800 cites W1987308757 @default.
- W2093527800 cites W1989289268 @default.
- W2093527800 cites W1990247684 @default.
- W2093527800 cites W1990749189 @default.
- W2093527800 cites W1990956809 @default.
- W2093527800 cites W1990995698 @default.
- W2093527800 cites W1998976196 @default.
- W2093527800 cites W2008379702 @default.
- W2093527800 cites W2011580247 @default.
- W2093527800 cites W2012337697 @default.
- W2093527800 cites W2023873351 @default.
- W2093527800 cites W2035900036 @default.
- W2093527800 cites W2037646515 @default.
- W2093527800 cites W2039579794 @default.
- W2093527800 cites W2060215125 @default.
- W2093527800 cites W2061700186 @default.
- W2093527800 cites W2061704745 @default.
- W2093527800 cites W2068623400 @default.
- W2093527800 cites W2069938223 @default.
- W2093527800 cites W2080093026 @default.
- W2093527800 cites W2082796078 @default.
- W2093527800 cites W2087920955 @default.
- W2093527800 cites W2093521208 @default.
- W2093527800 cites W2093962878 @default.
- W2093527800 cites W2095347614 @default.
- W2093527800 cites W2096054930 @default.
- W2093527800 cites W2096794529 @default.
- W2093527800 cites W2108086395 @default.
- W2093527800 cites W2109716633 @default.
- W2093527800 cites W2121781216 @default.
- W2093527800 cites W2124620907 @default.
- W2093527800 cites W2126801593 @default.
- W2093527800 cites W2129687643 @default.
- W2093527800 cites W2134348354 @default.
- W2093527800 cites W2135954438 @default.
- W2093527800 cites W2137434813 @default.
- W2093527800 cites W2141488468 @default.
- W2093527800 cites W2141976152 @default.
- W2093527800 cites W2150038290 @default.
- W2093527800 cites W2160348999 @default.
- W2093527800 cites W2161234475 @default.
- W2093527800 cites W2164785771 @default.
- W2093527800 cites W2166987747 @default.
- W2093527800 cites W2168427881 @default.
- W2093527800 cites W2171374570 @default.
- W2093527800 cites W2171712748 @default.
- W2093527800 cites W2624300556 @default.
- W2093527800 cites W2792139654 @default.
- W2093527800 cites W3209524011 @default.
- W2093527800 doi "https://doi.org/10.1016/s1357-2725(02)00343-6" @default.
- W2093527800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12672448" @default.
- W2093527800 hasPublicationYear "2003" @default.
- W2093527800 type Work @default.
- W2093527800 sameAs 2093527800 @default.
- W2093527800 citedByCount "107" @default.
- W2093527800 countsByYear W20935278002012 @default.
- W2093527800 countsByYear W20935278002013 @default.
- W2093527800 countsByYear W20935278002014 @default.
- W2093527800 countsByYear W20935278002015 @default.
- W2093527800 countsByYear W20935278002016 @default.
- W2093527800 countsByYear W20935278002017 @default.
- W2093527800 countsByYear W20935278002018 @default.
- W2093527800 countsByYear W20935278002019 @default.
- W2093527800 countsByYear W20935278002020 @default.
- W2093527800 countsByYear W20935278002022 @default.
- W2093527800 countsByYear W20935278002023 @default.
- W2093527800 crossrefType "journal-article" @default.
- W2093527800 hasAuthorship W2093527800A5038112377 @default.
- W2093527800 hasAuthorship W2093527800A5056765809 @default.
- W2093527800 hasAuthorship W2093527800A5070039006 @default.
- W2093527800 hasBestOaLocation W20935278001 @default.
- W2093527800 hasConcept C104317684 @default.
- W2093527800 hasConcept C134306372 @default.