FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093531092> ?p ?o ?g. }

• W2093531092 endingPage "1234" @default.
• W2093531092 startingPage "1225" @default.
• W2093531092 abstract "The requirements for interleukin (IL)-12/signal transducer and activator of transcription (Stat)-4 signaling and induction of T cell-specific interferon (IFN)-gamma expression in the development of T helper cell (Th)1-type pathology were examined in two different models of experimental colitis. In each model, abnormal reconstitution of the T cell compartment in immunodeficient mice by adoptive cell transfer leads to a wasting syndrome and inflammation of the colon, induced by IFN-gamma and tumor necrosis factor (TNF)-alpha-producing T cells. We show here that treatment with anti-IL-12 antibodies in one of the models, or reconstitution with T cells from Stat-4-deficient (Stat-4(null)) mice in both models resulted in a milder disease in the majority of recipient animals, compared with those that were left untreated or that had been reconstituted with wt cells. Protected mice in each group also harbored lower frequencies of IFN-gamma-producing T cells than did diseased mice, suggesting that effects on wasting and colitis resulted from the attenuation of IFN-gamma expression by T cells. To test whether the development of pathogenic T cells in the two colitis models was directly dependent on T cell-specific IFN-gamma expression, IFN-gammanull donors were used for T cell reconstitution in each system. Surprisingly, large numbers of IFN-gammanull-reconstituted mice developed wasting and colitis, which in many cases was of comparable severity to that seen in animals reconstituted with wt cells. Furthermore, T cells from these animals expressed TNF-alpha, demonstrating that they had retained the ability to produce another proinflammatory cytokine. Taken together, these results demonstrate that in some forms of chronic experimental colitis the development of pathogenic T cells is influenced predominantly, though not exclusively, by IL-12 via the actions of Stat-4 proteins. Furthermore, our data suggest that in the models of colitis studied here the effects of IL-12/Stat-4 or other Th1 promoting pathways are not limited to the induction of IFN-gamma gene expression in T lymphocytes." @default.
• W2093531092 created "2016-06-24" @default.
• W2093531092 creator A5013948185 @default.
• W2093531092 creator A5015340386 @default.
• W2093531092 creator A5028317965 @default.
• W2093531092 creator A5034685257 @default.
• W2093531092 creator A5035312083 @default.
• W2093531092 creator A5049800814 @default.
• W2093531092 creator A5081100336 @default.
• W2093531092 creator A5082623488 @default.
• W2093531092 date "1998-04-20" @default.
• W2093531092 modified "2023-10-18" @default.
• W2093531092 title "T Cell–mediated Pathology in Two Models of Experimental Colitis Depends Predominantly on the Interleukin 12/Signal Transducer and Activator of Transcription (Stat)-4 Pathway, but Is Not Conditional on Interferon γ Expression by T Cells" @default.
• W2093531092 cites W1485828435 @default.
• W2093531092 cites W1522816379 @default.
• W2093531092 cites W1580932873 @default.
• W2093531092 cites W1582445354 @default.
• W2093531092 cites W1894525365 @default.
• W2093531092 cites W1958363133 @default.
• W2093531092 cites W1969241777 @default.
• W2093531092 cites W1971119469 @default.
• W2093531092 cites W1971685694 @default.
• W2093531092 cites W1975588465 @default.
• W2093531092 cites W1976195770 @default.
• W2093531092 cites W1989210966 @default.
• W2093531092 cites W1998295547 @default.
• W2093531092 cites W2002061924 @default.
• W2093531092 cites W2003796602 @default.
• W2093531092 cites W2012628280 @default.
• W2093531092 cites W2018075167 @default.
• W2093531092 cites W2030778014 @default.
• W2093531092 cites W2032980904 @default.
• W2093531092 cites W2044069347 @default.
• W2093531092 cites W2048790064 @default.
• W2093531092 cites W2051705414 @default.
• W2093531092 cites W2062922499 @default.
• W2093531092 cites W2063053561 @default.
• W2093531092 cites W2069929656 @default.
• W2093531092 cites W2070319044 @default.
• W2093531092 cites W2074978521 @default.
• W2093531092 cites W2077195469 @default.
• W2093531092 cites W2083345299 @default.
• W2093531092 cites W2086715846 @default.
• W2093531092 cites W2089262366 @default.
• W2093531092 cites W2090831304 @default.
• W2093531092 cites W2107860814 @default.
• W2093531092 cites W2108473659 @default.
• W2093531092 cites W2109506765 @default.
• W2093531092 cites W2112812475 @default.
• W2093531092 cites W2114829069 @default.
• W2093531092 cites W2116723397 @default.
• W2093531092 cites W2118202213 @default.
• W2093531092 cites W2124576546 @default.
• W2093531092 cites W2141679700 @default.
• W2093531092 cites W2142948237 @default.
• W2093531092 cites W2160875559 @default.
• W2093531092 cites W2162888477 @default.
• W2093531092 cites W2165588484 @default.
• W2093531092 cites W2168524781 @default.
• W2093531092 cites W2171831396 @default.
• W2093531092 cites W234681446 @default.
• W2093531092 cites W2398863832 @default.
• W2093531092 cites W2404854108 @default.
• W2093531092 cites W4255846328 @default.
• W2093531092 doi "https://doi.org/10.1084/jem.187.8.1225" @default.
• W2093531092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2212228" @default.
• W2093531092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9547334" @default.
• W2093531092 hasPublicationYear "1998" @default.
• W2093531092 type Work @default.
• W2093531092 sameAs 2093531092 @default.
• W2093531092 citedByCount "283" @default.
• W2093531092 countsByYear W20935310922012 @default.
• W2093531092 countsByYear W20935310922013 @default.
• W2093531092 countsByYear W20935310922014 @default.
• W2093531092 countsByYear W20935310922015 @default.
• W2093531092 countsByYear W20935310922016 @default.
• W2093531092 countsByYear W20935310922017 @default.
• W2093531092 countsByYear W20935310922018 @default.
• W2093531092 countsByYear W20935310922019 @default.
• W2093531092 countsByYear W20935310922020 @default.
• W2093531092 countsByYear W20935310922021 @default.
• W2093531092 countsByYear W20935310922022 @default.
• W2093531092 countsByYear W20935310922023 @default.
• W2093531092 crossrefType "journal-article" @default.
• W2093531092 hasAuthorship W2093531092A5013948185 @default.
• W2093531092 hasAuthorship W2093531092A5015340386 @default.
• W2093531092 hasAuthorship W2093531092A5028317965 @default.
• W2093531092 hasAuthorship W2093531092A5034685257 @default.
• W2093531092 hasAuthorship W2093531092A5035312083 @default.
• W2093531092 hasAuthorship W2093531092A5049800814 @default.
• W2093531092 hasAuthorship W2093531092A5081100336 @default.
• W2093531092 hasAuthorship W2093531092A5082623488 @default.
• W2093531092 hasBestOaLocation W20935310921 @default.
• W2093531092 hasConcept C171958077 @default.
• W2093531092 hasConcept C17991360 @default.
• W2093531092 hasConcept C203014093 @default.
• W2093531092 hasConcept C2775862500 @default.
• W2093531092 hasConcept C2776090121 @default.

• next