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- W2093532681 abstract "HPRT-deficient EB-virus transformed human lymphoblasts show decreased levels of ATP and GTP compared with control lymphoblasts. This decrease was not consistent. The ATP content of the HPRT-deficient cells decreased to a significantly lower level than in control cells under unfavourable nutritional conditions, but not with frequent changes of medium. There was also a significant decrease in ADP-ribosylation in these cells. The cells showed a significant positive correlation between ATP content and poly(ADP-ribose) synthetase activity and an inverse correlation between NAD content and poly(ADP-ribose) synthetase activity, as NAD is the substrate for this enzyme. ADP-ribosylation is essential in many cellular processes including DNA repair and cell differentiation. So a decrease in ADP-ribosylation of nuclear protein may lead to decreased DNA repair. This may be a factor in explaining the long term deterioration of brain and testicular function in the Lesch-Nyhan Syndrome." @default.
- W2093532681 created "2016-06-24" @default.
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- W2093532681 date "1988-07-01" @default.
- W2093532681 modified "2023-10-18" @default.
- W2093532681 title "92 REDUCED PURINE NUCLEOTIDE CONTENT AND POLY(ADP-RIBOSE) SYNTHETASE ACTIVITY IN HPRT-DEFICIENT HUMAN LYMPHOBLASTS" @default.
- W2093532681 doi "https://doi.org/10.1203/00006450-198807000-00116" @default.
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