Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093539418> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2093539418 endingPage "404" @default.
- W2093539418 startingPage "399" @default.
- W2093539418 abstract "The plasma binding of prednisolone was studied in twenty normal volunteers and twenty rheumatoid arthritis patients. An in vitro assessment of the binding following the addition of prednisolone, prednisone, and hydrocortisone to the plasmas obtained from the subjects showed significant differences in the percentage of prednisolone bound. However, the differences observed were regarded as clinically insignificant. The plasma protein binding was determined by an in vitro equilibrium dialysis of the individual plasma samples at 37° C. Prednisolone levels on both sides of the dialysis membrane were determined using radioactivity and HPLC analytical methodologies. The percentages of prednisolone bound calculated from the analytical results of either the radiochemical or HPLC method were not significantly different. The change in the percentage of prednisolone bound to plasma proteins was studied as a function of the total prednisolone plasma concentration in a normal volunteer and in a systemic lupus erythematosis patient. As a result of prednisolone binding to both transcortin and albumin, the binding of prednisolone changes as a function of prednisolone concentration. The binding data were fitted using nonlinear least squares regression, and the affinity constants for the binding of prednisolone to transcortin and albumin were estimated." @default.
- W2093539418 created "2016-06-24" @default.
- W2093539418 creator A5001003746 @default.
- W2093539418 creator A5013873363 @default.
- W2093539418 creator A5031519618 @default.
- W2093539418 creator A5074275108 @default.
- W2093539418 creator A5091138235 @default.
- W2093539418 date "1979-11-01" @default.
- W2093539418 modified "2023-09-25" @default.
- W2093539418 title "Plasma protein binding of prednisolone in normal volunteers and arthritic patients" @default.
- W2093539418 cites W1538795472 @default.
- W2093539418 cites W1568566686 @default.
- W2093539418 cites W168040927 @default.
- W2093539418 cites W1778202141 @default.
- W2093539418 cites W1933300979 @default.
- W2093539418 cites W1963597760 @default.
- W2093539418 cites W1979225610 @default.
- W2093539418 cites W1992119129 @default.
- W2093539418 cites W2140497896 @default.
- W2093539418 cites W2150819743 @default.
- W2093539418 cites W2344160023 @default.
- W2093539418 doi "https://doi.org/10.1007/bf00568200" @default.
- W2093539418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/527636" @default.
- W2093539418 hasPublicationYear "1979" @default.
- W2093539418 type Work @default.
- W2093539418 sameAs 2093539418 @default.
- W2093539418 citedByCount "25" @default.
- W2093539418 countsByYear W20935394182013 @default.
- W2093539418 countsByYear W20935394182018 @default.
- W2093539418 crossrefType "journal-article" @default.
- W2093539418 hasAuthorship W2093539418A5001003746 @default.
- W2093539418 hasAuthorship W2093539418A5013873363 @default.
- W2093539418 hasAuthorship W2093539418A5031519618 @default.
- W2093539418 hasAuthorship W2093539418A5074275108 @default.
- W2093539418 hasAuthorship W2093539418A5091138235 @default.
- W2093539418 hasBestOaLocation W20935394182 @default.
- W2093539418 hasConcept C126322002 @default.
- W2093539418 hasConcept C134018914 @default.
- W2093539418 hasConcept C146543888 @default.
- W2093539418 hasConcept C185592680 @default.
- W2093539418 hasConcept C2776125364 @default.
- W2093539418 hasConcept C2776715498 @default.
- W2093539418 hasConcept C2777575956 @default.
- W2093539418 hasConcept C2778720950 @default.
- W2093539418 hasConcept C51639874 @default.
- W2093539418 hasConcept C55493867 @default.
- W2093539418 hasConcept C71924100 @default.
- W2093539418 hasConcept C81358767 @default.
- W2093539418 hasConcept C90134679 @default.
- W2093539418 hasConceptScore W2093539418C126322002 @default.
- W2093539418 hasConceptScore W2093539418C134018914 @default.
- W2093539418 hasConceptScore W2093539418C146543888 @default.
- W2093539418 hasConceptScore W2093539418C185592680 @default.
- W2093539418 hasConceptScore W2093539418C2776125364 @default.
- W2093539418 hasConceptScore W2093539418C2776715498 @default.
- W2093539418 hasConceptScore W2093539418C2777575956 @default.
- W2093539418 hasConceptScore W2093539418C2778720950 @default.
- W2093539418 hasConceptScore W2093539418C51639874 @default.
- W2093539418 hasConceptScore W2093539418C55493867 @default.
- W2093539418 hasConceptScore W2093539418C71924100 @default.
- W2093539418 hasConceptScore W2093539418C81358767 @default.
- W2093539418 hasConceptScore W2093539418C90134679 @default.
- W2093539418 hasIssue "6" @default.
- W2093539418 hasLocation W20935394181 @default.
- W2093539418 hasLocation W20935394182 @default.
- W2093539418 hasLocation W20935394183 @default.
- W2093539418 hasOpenAccess W2093539418 @default.
- W2093539418 hasPrimaryLocation W20935394181 @default.
- W2093539418 hasRelatedWork W119486356 @default.
- W2093539418 hasRelatedWork W1963490606 @default.
- W2093539418 hasRelatedWork W1996591965 @default.
- W2093539418 hasRelatedWork W2048249720 @default.
- W2093539418 hasRelatedWork W2054395385 @default.
- W2093539418 hasRelatedWork W2067839819 @default.
- W2093539418 hasRelatedWork W2134540674 @default.
- W2093539418 hasRelatedWork W2140497896 @default.
- W2093539418 hasRelatedWork W2145318311 @default.
- W2093539418 hasRelatedWork W2401543985 @default.
- W2093539418 hasVolume "16" @default.
- W2093539418 isParatext "false" @default.
- W2093539418 isRetracted "false" @default.
- W2093539418 magId "2093539418" @default.
- W2093539418 workType "article" @default.