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• W2093541036 abstract "Stem cells technology can result in a paradigm shift in medicine therapeutic armamentarium In the recent past, researches on tissue engineering and regenerative medicine (TERM) have gained momentum as the next generation technology for transplantation of whole organ and tissue for diseased/malfunctioned organs, although the notion of regeneration ability of a lost tissue is already revealed to mankind for several years [1]. Each year, millions of patients suffer from end-stage organ disease or tissue loss, resulting in high mortality rate due to lack of adequate donors and clinical limitations of surgical therapies [2]. Addressing such formidable challenges, the growing interest in regenerative medicine coupled with extraordinary advances on stem cells science can likely result in a paradigm shift in medicine therapeutic armamentarium [3,4]. This will ultimately lead to considerable biological solutions to surmount typical/simple medical shortcomings. Very recently, three stem cell products approved from Korea Food and Drug Administration (KFDA), were launched in the Korean market in 2012, which includes world’s first-time reported autologous bone marrow derived stem cells (BMSC), autologous adipose derived stem cell (ADSC) and allogenic umbilical cord derived stem cell (UBMSC) for the treatment of myocardial infarction, Chron’s disease and chondyle defect, respectively [1]. Additionally, over one – two hundred clinical trial Phase I, II, III with a wide arena of scientific field is under development throughout the world. This may be a burgeoning step towards the advancement of regenerative medicine compared with that of conventional medication therapy however, their impressions will provide a platform for future advances in stem cell technology applications. The basic concept of TERM is to manipulate the extracellular environment for cells inherently present in the body to enhance their biological potentials for tissue generation [5]. To realize a successful therapy using regenerative medicinal technique, triad ingredients are fundamentals, that is: (i) specific/desired cells as harvested and dissociated primary cells, adult stem cell, embryonic stem cell (ESC) and induced pluripotent cell (iPS); (ii) natural or artificial extracellular matrix (ECM) known as scaffolds, provides a favorable environment for cells adhesion, growth resulting in desired number of healthy cells with specific functions; (iii) biomolecules including growth factors, cytokines and phospholipids which furnishes the nourishment for cell proliferation and/or differentiation by up-regulation or down-regulation of specific proteins, receptors, etc. [1,6]" @default.
• W2093541036 created "2016-06-24" @default.
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• W2093541036 date "2014-10-01" @default.
• W2093541036 modified "2023-09-23" @default.
• W2093541036 title "Importance of controlled delivery systems for regenerative therapeutics" @default.
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• W2093541036 doi "https://doi.org/10.4155/tde.14.80" @default.
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