Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093545531> ?p ?o ?g. }
- W2093545531 endingPage "584" @default.
- W2093545531 startingPage "577" @default.
- W2093545531 abstract "We here show that GLP-1 and the long-acting GLP-1 analogue, liraglutide, interfere with diabetes-associated apoptotic processes in the β-cell. Studies using primary neonatal rat islets showed that native GLP-1 and liraglutide inhibited both cytokine- and free fatty acid-induced apoptosis in a dose-dependent manner. The anti-apoptotic effect of liraglutide was mediated by the GLP-1 receptor as the specific GLP-1 receptor antagonist, exendin(9–39), blocked the effects. The adenylate cyclase activator, forskolin, had an anti-apoptotic effect similar to those of GLP-1 and liraglutide indicating that the effect was cAMP-mediated. Blocking the PI3 kinase pathway using wortmannin but not the MAP kinase pathways by PD98059 inhibited the effects of liraglutide. In conclusion, GLP-1 receptor activation has anti-apoptotic effect on both cytokine, and free fatty acid-induced apoptosis in primary islet-cells, thus suggesting that the long-acting GLP-1 analogue, liraglutide, may be useful for retaining β-cell mass in both type 1 and type 2 diabetic patients." @default.
- W2093545531 created "2016-06-24" @default.
- W2093545531 creator A5016932754 @default.
- W2093545531 creator A5020402916 @default.
- W2093545531 creator A5023731487 @default.
- W2093545531 creator A5049273814 @default.
- W2093545531 creator A5075774899 @default.
- W2093545531 creator A5081782555 @default.
- W2093545531 creator A5088627727 @default.
- W2093545531 creator A5091874414 @default.
- W2093545531 date "2005-05-01" @default.
- W2093545531 modified "2023-10-18" @default.
- W2093545531 title "The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro" @default.
- W2093545531 cites W1501945560 @default.
- W2093545531 cites W1965676092 @default.
- W2093545531 cites W1977215449 @default.
- W2093545531 cites W1979636493 @default.
- W2093545531 cites W1979950901 @default.
- W2093545531 cites W1986331352 @default.
- W2093545531 cites W2020468088 @default.
- W2093545531 cites W2022090845 @default.
- W2093545531 cites W2026348270 @default.
- W2093545531 cites W2029391105 @default.
- W2093545531 cites W2038545492 @default.
- W2093545531 cites W2040278047 @default.
- W2093545531 cites W2052311839 @default.
- W2093545531 cites W2057692152 @default.
- W2093545531 cites W2063693981 @default.
- W2093545531 cites W2066487478 @default.
- W2093545531 cites W2075858095 @default.
- W2093545531 cites W2086341274 @default.
- W2093545531 cites W2088472722 @default.
- W2093545531 cites W2090007082 @default.
- W2093545531 cites W2100614900 @default.
- W2093545531 cites W2102400698 @default.
- W2093545531 cites W2105497606 @default.
- W2093545531 cites W2105532009 @default.
- W2093545531 cites W2117983863 @default.
- W2093545531 cites W2120653342 @default.
- W2093545531 cites W2127409471 @default.
- W2093545531 cites W2140137473 @default.
- W2093545531 cites W2140992882 @default.
- W2093545531 cites W2141160128 @default.
- W2093545531 cites W2143847100 @default.
- W2093545531 cites W2146333376 @default.
- W2093545531 cites W2149502431 @default.
- W2093545531 cites W2153342269 @default.
- W2093545531 cites W2157263909 @default.
- W2093545531 cites W2159243532 @default.
- W2093545531 cites W2161144814 @default.
- W2093545531 cites W2169760435 @default.
- W2093545531 cites W2328786770 @default.
- W2093545531 cites W4233330545 @default.
- W2093545531 cites W4239718055 @default.
- W2093545531 cites W96529884 @default.
- W2093545531 doi "https://doi.org/10.1016/j.bbrc.2005.03.013" @default.
- W2093545531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15796922" @default.
- W2093545531 hasPublicationYear "2005" @default.
- W2093545531 type Work @default.
- W2093545531 sameAs 2093545531 @default.
- W2093545531 citedByCount "161" @default.
- W2093545531 countsByYear W20935455312012 @default.
- W2093545531 countsByYear W20935455312013 @default.
- W2093545531 countsByYear W20935455312014 @default.
- W2093545531 countsByYear W20935455312015 @default.
- W2093545531 countsByYear W20935455312016 @default.
- W2093545531 countsByYear W20935455312017 @default.
- W2093545531 countsByYear W20935455312018 @default.
- W2093545531 countsByYear W20935455312019 @default.
- W2093545531 countsByYear W20935455312020 @default.
- W2093545531 countsByYear W20935455312021 @default.
- W2093545531 countsByYear W20935455312023 @default.
- W2093545531 crossrefType "journal-article" @default.
- W2093545531 hasAuthorship W2093545531A5016932754 @default.
- W2093545531 hasAuthorship W2093545531A5020402916 @default.
- W2093545531 hasAuthorship W2093545531A5023731487 @default.
- W2093545531 hasAuthorship W2093545531A5049273814 @default.
- W2093545531 hasAuthorship W2093545531A5075774899 @default.
- W2093545531 hasAuthorship W2093545531A5081782555 @default.
- W2093545531 hasAuthorship W2093545531A5088627727 @default.
- W2093545531 hasAuthorship W2093545531A5091874414 @default.
- W2093545531 hasConcept C126322002 @default.
- W2093545531 hasConcept C134018914 @default.
- W2093545531 hasConcept C170493617 @default.
- W2093545531 hasConcept C185280430 @default.
- W2093545531 hasConcept C185592680 @default.
- W2093545531 hasConcept C190283241 @default.
- W2093545531 hasConcept C2776398474 @default.
- W2093545531 hasConcept C2777180221 @default.
- W2093545531 hasConcept C2778308172 @default.
- W2093545531 hasConcept C2778938600 @default.
- W2093545531 hasConcept C2779276759 @default.
- W2093545531 hasConcept C2781308992 @default.
- W2093545531 hasConcept C55493867 @default.
- W2093545531 hasConcept C555293320 @default.
- W2093545531 hasConcept C71924100 @default.
- W2093545531 hasConcept C86554907 @default.
- W2093545531 hasConcept C86803240 @default.