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- W2093548360 abstract "Approximately 3% of the world population is infected with hepatitis C virus (HCV), causing a serious public health burden. Like other positive-strand RNA viruses, HCV assembles replicase complexes in association with cellular membranes and produces progeny RNA genomes through negative-strand intermediates. The viral proteins required for RNA replication are nonstructural (NS) proteins NS3 to NS5B. Owing to many obstacles and limitations in structural characterization of proteins and complexes with multiple transmembrane segments, attempts to understand the assembly and action of the HCV replicase complex have been challenging. Nevertheless, great progress has been made in obtaining structural information for several replicase components, providing insights into some aspects of the viral genome replication machinery." @default.
- W2093548360 created "2016-06-24" @default.
- W2093548360 creator A5019683467 @default.
- W2093548360 creator A5021886786 @default.
- W2093548360 date "2013-04-01" @default.
- W2093548360 modified "2023-10-16" @default.
- W2093548360 title "Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function" @default.
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- W2093548360 doi "https://doi.org/10.1016/j.coviro.2013.03.013" @default.
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