FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093549239> ?p ?o ?g. }

• W2093549239 endingPage "875" @default.
• W2093549239 startingPage "875" @default.
• W2093549239 abstract "This study aimed at evaluating the anti-inflammatory properties of a pomegranate fruit husk (PomH) polyphenolic extract, rich in punicalagin, using Caco-2 cells, an in vitro model of human intestinal epithelium. Differentiated cells in bicameral inserts were pretreated or not with a PomH extract or punicalagin, as reference, at the apical side, representing the intestinal lumen. Inflammation was then induced with a cocktail of cytokines (Il-1β, TNFα and IFNγ) and LPS. After 24 h incubation, 3 pro-inflammatory markers, i.e., interleukin (IL)-6, IL-8 and monocyte chemoattractant protein (MCP)-1, were assayed both at their gene transcription (qRT-PCR) and secretion (ELISA) levels. As previously described, the pro-inflammatory cocktail significantly stimulated these 3 markers, at the gene transcript and secretion levels. In inflamed cells, a significant down-regulation of the transcription of the genes encoding IL-6 and MCP-1 was observed in the presence of the PomH extract or punicalagin, while IL-8 transcription was unaffected. Both treatments also decreased the amounts of the 3 proteins with dose-response effects, but only in the apical compartment. A lowered ELISA response was also observed when either IL-6, IL-8 or MCP-1 were mixed with punicalagin in a cell-free culture medium, indicating a direct molecular interaction. In conclusion, the punicalagin-rich PomH extract tested showed anti-inflammatory properties in the Caco-2 in vitro intestinal model. It acted both on the pro-inflammatory gene transcription and protein levels, the later phenomenon being possibly due to a direct molecular trapping. These data suggest that pomegranate husk could be an interesting natural source contributing to prevent intestinal chronic inflammation." @default.
• W2093549239 created "2016-06-24" @default.
• W2093549239 creator A5005353089 @default.
• W2093549239 creator A5007688709 @default.
• W2093549239 creator A5015269011 @default.
• W2093549239 creator A5016295209 @default.
• W2093549239 creator A5024804068 @default.
• W2093549239 creator A5032605982 @default.
• W2093549239 creator A5044571561 @default.
• W2093549239 date "2012-01-01" @default.
• W2093549239 modified "2023-10-01" @default.
• W2093549239 title "Anti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestine" @default.
• W2093549239 cites W1531257775 @default.
• W2093549239 cites W1957003034 @default.
• W2093549239 cites W1969180242 @default.
• W2093549239 cites W1972268592 @default.
• W2093549239 cites W1973058491 @default.
• W2093549239 cites W1974810494 @default.
• W2093549239 cites W1975375148 @default.
• W2093549239 cites W1979948289 @default.
• W2093549239 cites W1984196078 @default.
• W2093549239 cites W1984447537 @default.
• W2093549239 cites W1988357566 @default.
• W2093549239 cites W2002664765 @default.
• W2093549239 cites W2006758543 @default.
• W2093549239 cites W2009864927 @default.
• W2093549239 cites W2010120018 @default.
• W2093549239 cites W2012101183 @default.
• W2093549239 cites W2013822780 @default.
• W2093549239 cites W2015123436 @default.
• W2093549239 cites W2017739484 @default.
• W2093549239 cites W2018882072 @default.
• W2093549239 cites W2019326608 @default.
• W2093549239 cites W2020932917 @default.
• W2093549239 cites W2028078823 @default.
• W2093549239 cites W2030371658 @default.
• W2093549239 cites W2044623277 @default.
• W2093549239 cites W2051495414 @default.
• W2093549239 cites W2053362319 @default.
• W2093549239 cites W2053885716 @default.
• W2093549239 cites W2055707661 @default.
• W2093549239 cites W2061702898 @default.
• W2093549239 cites W2065877008 @default.
• W2093549239 cites W2074802791 @default.
• W2093549239 cites W2079426150 @default.
• W2093549239 cites W2081012360 @default.
• W2093549239 cites W2083061972 @default.
• W2093549239 cites W2084856643 @default.
• W2093549239 cites W2093682191 @default.
• W2093549239 cites W2099979796 @default.
• W2093549239 cites W2101571252 @default.
• W2093549239 cites W2105234557 @default.
• W2093549239 cites W2107429944 @default.
• W2093549239 cites W2118877038 @default.
• W2093549239 cites W2119944195 @default.
• W2093549239 cites W2123167112 @default.
• W2093549239 cites W2124162221 @default.
• W2093549239 cites W2127339426 @default.
• W2093549239 cites W2141462478 @default.
• W2093549239 cites W2146696997 @default.
• W2093549239 cites W2164991605 @default.
• W2093549239 cites W2166450414 @default.
• W2093549239 cites W4229948187 @default.
• W2093549239 cites W4232534952 @default.
• W2093549239 doi "https://doi.org/10.1039/c2fo10258g" @default.
• W2093549239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22733173" @default.
• W2093549239 hasPublicationYear "2012" @default.
• W2093549239 type Work @default.
• W2093549239 sameAs 2093549239 @default.
• W2093549239 citedByCount "60" @default.
• W2093549239 countsByYear W20935492392013 @default.
• W2093549239 countsByYear W20935492392014 @default.
• W2093549239 countsByYear W20935492392015 @default.
• W2093549239 countsByYear W20935492392016 @default.
• W2093549239 countsByYear W20935492392017 @default.
• W2093549239 countsByYear W20935492392018 @default.
• W2093549239 countsByYear W20935492392019 @default.
• W2093549239 countsByYear W20935492392020 @default.
• W2093549239 countsByYear W20935492392021 @default.
• W2093549239 countsByYear W20935492392022 @default.
• W2093549239 countsByYear W20935492392023 @default.
• W2093549239 crossrefType "journal-article" @default.
• W2093549239 hasAuthorship W2093549239A5005353089 @default.
• W2093549239 hasAuthorship W2093549239A5007688709 @default.
• W2093549239 hasAuthorship W2093549239A5015269011 @default.
• W2093549239 hasAuthorship W2093549239A5016295209 @default.
• W2093549239 hasAuthorship W2093549239A5024804068 @default.
• W2093549239 hasAuthorship W2093549239A5032605982 @default.
• W2093549239 hasAuthorship W2093549239A5044571561 @default.
• W2093549239 hasConcept C138885662 @default.
• W2093549239 hasConcept C144027150 @default.
• W2093549239 hasConcept C153911025 @default.
• W2093549239 hasConcept C164027704 @default.
• W2093549239 hasConcept C179926584 @default.
• W2093549239 hasConcept C185592680 @default.
• W2093549239 hasConcept C193176779 @default.
• W2093549239 hasConcept C202751555 @default.
• W2093549239 hasConcept C203014093 @default.

• next