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• W2093554328 abstract "To determine whether germ cells perform any function in gonadal sexual differentiation, development of gonads in the medaka, Oryzias latipes, after exposure to busulfan was investigated. Busulfan suppressed proliferation of early germ cells, thus significantly reducing the number of germ cells and generating regions without germ cells in the developing gonads. Globular structures were observed in the parenchyma in these regions. The structure was male specific, developed at the same time as acinus (seminiferous tubule precursor), surrounded by the basal lamina, and contained characteristic desmosomes. These results strongly suggest that these globular structures are the precursors of seminiferous tubules devoid of germ cells. In the ovary, no follicles were observed but a well-developed ovarian cavity was evident. From these results we conclude that differentiation of gonadal parenchyma cells, except for follicular ones, is not germ cell dependent, though morphological differentiation of the somatic cells seems to follow the differentiation of germ cells. J. Exp. Zool. 290:402–410, 2001. © 2001 Wiley-Liss, Inc." @default.
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• W2093554328 date "2001-01-01" @default.
• W2093554328 modified "2023-10-17" @default.
• W2093554328 title "Sexual differentiation of germ cell deficient gonads in the medaka,Oryzias latipes" @default.
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• W2093554328 doi "https://doi.org/10.1002/jez.1081" @default.
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