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• W2093558100 abstract "Hydrogen sulfide (H2S) is recognized as an important gaseous signaling molecule in mammalian tissues and exerts its modulating functions of different systems via targeting different ion channels and receptors. H2S can be synthesized from l-cysteine by cystathionine β-synthetase (CBS) or cystathionine γ-lyase (CSE). It has been reported recently that H2S can be synthesized and released in rat adrenal medulla chromaffin cells (AMCs) which play a critical role in the regulation of stress response by releasing catecholamine (CA). In the present study, we combined amperometry and whole-cell patch-clamp recording to explore the direct effect of exogenous H2S on CA release in AMCs and the underlying ionic mechanism. Amperometry showed that local application of NaHS, the H2S donor, evoked CA release from AMCs. Furthermore, the CA secretory response to NaHS was totally blocked by removing extracellular Ca2+. Whole-cell patch-clamp experiments showed that H2S-induced CA release is produced by membrane depolarization generated by an inhibition of Ca2+-activated K+ current [IK(Ca) current]. We conclude that H2S is capable of directly inducing CA release by inhibiting the IK(Ca) current. This conclusion indicates that H2S may involve in the response of adrenal medulla to stress by modulating IK(Ca) current and CA release in mammalian animals." @default.
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• W2093558100 date "2012-12-01" @default.
• W2093558100 modified "2023-09-30" @default.
• W2093558100 title "H2S induces catecholamine secretion in rat adrenal chromaffin cells" @default.
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• W2093558100 doi "https://doi.org/10.1016/j.tox.2012.07.008" @default.
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