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- W2093558103 abstract "Dietary potassium (K+) intake has antihypertensive effects, prevents strokes, and improves cardiovascular outcomes. The underlying mechanism for these beneficial effects of high K+ diets may include vasodilation, enhanced urine flow, reduced renal renin release, and negative sodium (Na+) balance. Indeed, several studies demonstrate that dietary K+ intake induces renal Na+ loss despite elevated plasma aldosterone. This review briefly highlights the epidemiological and experimental evidences for the effects of dietary K+ on arterial blood pressure. It discusses the pivotal role of the renal distal tubule for the regulation of urinary K+ and Na+ excretion and blood pressure and highlights that it depends on the coordinated interaction of different nephron portions, epithelial cell types, and various ion channels, transporters, and ATPases. Moreover, we discuss the relevance of aldosterone and aldosterone-independent factors in mediating the effects of an altered K+ intake on renal K+ and Na+ handling. Particular focus is given to findings suggesting that an aldosterone-independent downregulation of the thiazide-sensitive NaCl cotransporter significantly contributes to the natriuretic and antihypertensive effect of a K+-rich diet. Last but not least, we refer to the complex signaling pathways enabling the kidney to adapt its function to the homeostatic needs in response to an altered K+ intake. Future work will have to further address the underlying cellular and molecular mechanism and to elucidate, among others, how an altered dietary K+ intake is sensed and how this signal is transmitted to the different epithelial cells lining the distal tubule." @default.
- W2093558103 created "2016-06-24" @default.
- W2093558103 creator A5016089333 @default.
- W2093558103 creator A5031639542 @default.
- W2093558103 creator A5064787909 @default.
- W2093558103 date "2015-01-06" @default.
- W2093558103 modified "2023-10-13" @default.
- W2093558103 title "Dietary potassium and the renal control of salt balance and blood pressure" @default.
- W2093558103 cites W1481480932 @default.
- W2093558103 cites W1535919368 @default.
- W2093558103 cites W1600338595 @default.
- W2093558103 cites W1920439767 @default.
- W2093558103 cites W1963514522 @default.
- W2093558103 cites W1963527725 @default.
- W2093558103 cites W1963635711 @default.
- W2093558103 cites W1964716749 @default.
- W2093558103 cites W1965407415 @default.
- W2093558103 cites W1969244514 @default.
- W2093558103 cites W1972417122 @default.
- W2093558103 cites W1972898308 @default.
- W2093558103 cites W1973967902 @default.
- W2093558103 cites W1975282060 @default.
- W2093558103 cites W1977518774 @default.
- W2093558103 cites W1979845477 @default.
- W2093558103 cites W1980805930 @default.
- W2093558103 cites W1981036549 @default.
- W2093558103 cites W1981054886 @default.
- W2093558103 cites W1981372032 @default.
- W2093558103 cites W1981586667 @default.
- W2093558103 cites W1981839032 @default.
- W2093558103 cites W1982498018 @default.
- W2093558103 cites W1983761633 @default.
- W2093558103 cites W1985793100 @default.
- W2093558103 cites W1986744506 @default.
- W2093558103 cites W1987514645 @default.
- W2093558103 cites W1989490275 @default.
- W2093558103 cites W1990662486 @default.
- W2093558103 cites W1992711212 @default.
- W2093558103 cites W1994087161 @default.
- W2093558103 cites W1994562335 @default.
- W2093558103 cites W1996690850 @default.
- W2093558103 cites W1997733329 @default.
- W2093558103 cites W2000448320 @default.
- W2093558103 cites W2002563649 @default.
- W2093558103 cites W2003231835 @default.
- W2093558103 cites W2006423155 @default.
- W2093558103 cites W2007555006 @default.
- W2093558103 cites W2007850369 @default.
- W2093558103 cites W2009784372 @default.
- W2093558103 cites W2010512879 @default.
- W2093558103 cites W2012329129 @default.
- W2093558103 cites W2013154098 @default.
- W2093558103 cites W2013178091 @default.
- W2093558103 cites W201492019 @default.
- W2093558103 cites W2015220345 @default.
- W2093558103 cites W2015392008 @default.
- W2093558103 cites W2015721729 @default.
- W2093558103 cites W2020056111 @default.
- W2093558103 cites W2020869146 @default.
- W2093558103 cites W2021508287 @default.
- W2093558103 cites W2022008842 @default.
- W2093558103 cites W2025575466 @default.
- W2093558103 cites W2029010071 @default.
- W2093558103 cites W2029268686 @default.
- W2093558103 cites W2029338338 @default.
- W2093558103 cites W2029767886 @default.
- W2093558103 cites W2030194230 @default.
- W2093558103 cites W2030739173 @default.
- W2093558103 cites W2034655787 @default.
- W2093558103 cites W2037955097 @default.
- W2093558103 cites W2038748882 @default.
- W2093558103 cites W2039492547 @default.
- W2093558103 cites W2041815899 @default.
- W2093558103 cites W2045699868 @default.
- W2093558103 cites W2047764483 @default.
- W2093558103 cites W2048332551 @default.
- W2093558103 cites W2048708991 @default.
- W2093558103 cites W2048888251 @default.
- W2093558103 cites W2050220178 @default.
- W2093558103 cites W2050767894 @default.
- W2093558103 cites W2050875396 @default.
- W2093558103 cites W2056496810 @default.
- W2093558103 cites W2057527228 @default.
- W2093558103 cites W2059116113 @default.
- W2093558103 cites W2063277354 @default.
- W2093558103 cites W2065548030 @default.
- W2093558103 cites W2066031126 @default.
- W2093558103 cites W2066394721 @default.
- W2093558103 cites W2066418121 @default.
- W2093558103 cites W2066970340 @default.
- W2093558103 cites W2067083162 @default.
- W2093558103 cites W2067541658 @default.
- W2093558103 cites W2068448909 @default.
- W2093558103 cites W2070327733 @default.
- W2093558103 cites W2070801881 @default.
- W2093558103 cites W2072427686 @default.
- W2093558103 cites W2072943898 @default.
- W2093558103 cites W2073881942 @default.