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• W2093559422 abstract "In artificial insemination industry bulls producing high volume of semen with relatively high concentration of sperm are very desirable since they ensure stable production of commercial straws especially in case of top bulls. The aim of the study was to screen the entire bull genome to identify markers and candidate genes underlying semen volume (SV) and total number of sperm (TNS) in ejaculate produced by Holstein-Friesian bulls. Data on semen production were retrieved from records of AI center and included a population of 877 Holstein-Friesian bulls. Each bull was genotyped using the Illumina BovineSNP50 BeadChip. Genome-wide association analysis was performed with the use of GoldenHelix SVS7 software. An additive model for Linear Regression Analysis was used to estimate the effect of SNP marker for SV and TNS. After Bonferroni correction, 3 markers located on chromosome 22 reached the highest significance (rs41625599, rs41584616, rs42012507) for both traits. In the vicinity of these significant markers 3 genes are located (DCP1A, SFMBT1, TMEM110). Moreover, marker rs110109069 located on chromosome 25 was significantly associated with TNS and marker rs42438348 located on chromosome 10 has been found to be associated with SV. Some additional candidate genes were suggested to be potentially involved in analyzed traits (GALC, PRKCD, PHF7, TLR9, SPATA7). Identifying SNPs associated with the lower total number of sperm may be very useful for early recognition of a young sire as less suitable for effective semen production in artificial insemination centers." @default.
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• W2093559422 date "2014-12-01" @default.
• W2093559422 modified "2023-09-30" @default.
• W2093559422 title "Genome-wide association study for semen volume and total number of sperm in Holstein-Friesian bulls" @default.
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• W2093559422 doi "https://doi.org/10.1016/j.anireprosci.2014.10.022" @default.
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