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- W2093565522 abstract "Although calmodulin (CaM) interaction with estrogen receptor alpha (ERα) has been known for more than two decades, it is only recently that the molecular mechanism of CaM-mediated regulation of ERα is beginning to emerge. Others and we have identified a putative calmodulin binding site (P295LMIKRSKKNSLALSTADQMVS317) in ERα, at the boundary between the hinge and the ligand binding domain. ERα mutations affecting its association with CaM have been reported to generate high basal, estrogen-independent transactivation activity, indicating that the P295–T317 sequence has an inhibitory function. Moreover, we found that a synthetic peptide (ERα17p: P295–T311) containing residues crucial for CaM binding exerts estrogenic effects on breast carcinoma cells. Finally, computer-aided conformational studies revealed that the CaM binding site might associate with a region located downstream in ERα (the β turn/H4 region), this association likely resulting in an auto-inhibitory folding of the receptor. Thus, we propose as a hypothesis that CaM acts as a positive regulator by relieving this ERα auto-inhibition." @default.
- W2093565522 created "2016-06-24" @default.
- W2093565522 creator A5011027831 @default.
- W2093565522 creator A5068430605 @default.
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- W2093565522 date "2008-09-01" @default.
- W2093565522 modified "2023-10-15" @default.
- W2093565522 title "Calmodulin, a regulatory partner of the estrogen receptor alpha in breast cancer cells" @default.
- W2093565522 cites W1607418737 @default.
- W2093565522 cites W1972523086 @default.
- W2093565522 cites W1979400580 @default.
- W2093565522 cites W1979613300 @default.
- W2093565522 cites W1982474381 @default.
- W2093565522 cites W1985046165 @default.
- W2093565522 cites W1991958056 @default.
- W2093565522 cites W1994530813 @default.
- W2093565522 cites W1996042529 @default.
- W2093565522 cites W1997562909 @default.
- W2093565522 cites W1998804942 @default.
- W2093565522 cites W1999186716 @default.
- W2093565522 cites W2002957145 @default.
- W2093565522 cites W2007203662 @default.
- W2093565522 cites W2008398027 @default.
- W2093565522 cites W2008559836 @default.
- W2093565522 cites W2009219941 @default.
- W2093565522 cites W2013074747 @default.
- W2093565522 cites W2013809140 @default.
- W2093565522 cites W2018018701 @default.
- W2093565522 cites W2018546792 @default.
- W2093565522 cites W2022639527 @default.
- W2093565522 cites W2023016547 @default.
- W2093565522 cites W2023270574 @default.
- W2093565522 cites W2025956185 @default.
- W2093565522 cites W2026948301 @default.
- W2093565522 cites W2027048981 @default.
- W2093565522 cites W2028768402 @default.
- W2093565522 cites W2036477406 @default.
- W2093565522 cites W2038208040 @default.
- W2093565522 cites W2039393537 @default.
- W2093565522 cites W2040353947 @default.
- W2093565522 cites W2044817633 @default.
- W2093565522 cites W2054564508 @default.
- W2093565522 cites W2055656313 @default.
- W2093565522 cites W2057786093 @default.
- W2093565522 cites W2059182387 @default.
- W2093565522 cites W2063064538 @default.
- W2093565522 cites W2064613822 @default.
- W2093565522 cites W2064844656 @default.
- W2093565522 cites W2067233094 @default.
- W2093565522 cites W2071095686 @default.
- W2093565522 cites W2071106600 @default.
- W2093565522 cites W2076501132 @default.
- W2093565522 cites W2077988230 @default.
- W2093565522 cites W2080174206 @default.
- W2093565522 cites W2084065267 @default.
- W2093565522 cites W2085700792 @default.
- W2093565522 cites W2087952711 @default.
- W2093565522 cites W2090921107 @default.
- W2093565522 cites W2091611649 @default.
- W2093565522 cites W2095507789 @default.
- W2093565522 cites W2101467600 @default.
- W2093565522 cites W2103309832 @default.
- W2093565522 cites W2118728497 @default.
- W2093565522 cites W2127226545 @default.
- W2093565522 cites W2133823889 @default.
- W2093565522 cites W2141466699 @default.
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- W2093565522 cites W2147859244 @default.
- W2093565522 cites W2150869416 @default.
- W2093565522 cites W2166546832 @default.
- W2093565522 cites W2170634115 @default.
- W2093565522 cites W2234832455 @default.
- W2093565522 cites W4211007332 @default.
- W2093565522 cites W4233298669 @default.
- W2093565522 cites W4238586496 @default.
- W2093565522 cites W4240126666 @default.
- W2093565522 cites W4251127352 @default.
- W2093565522 cites W4254152438 @default.
- W2093565522 doi "https://doi.org/10.1016/j.mce.2008.04.011" @default.
- W2093565522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18524472" @default.
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