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- W2093567462 abstract "In a canine model the tolerance of normal and surgically manipulated tissue to intraoperative radiotherapy (IORT) was investigated to provide guidelines for the clinical use of IORT in human cancer patients. A dose of 20 Gy IORT, with or without external beam radiotherapy, was generally well tolerated without significant increased treatment morbidity. Higher doses of IORT (over 30 Gy) have produced radiation-induced sarcomas in some animals followed over a long period. Therefore IORT should be used only in human cancer patients in well controlled studies, in which complications are well documented, and the possibility of radiation-induced malignancies in long-term survival should be considered." @default.
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- W2093567462 date "1989-12-01" @default.
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- W2093567462 title "Intraoperative Radiation Therapy-Induced Sarcomas in Dogs" @default.
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- W2093567462 doi "https://doi.org/10.2307/3577800" @default.
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