FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093570206> ?p ?o ?g. }

• W2093570206 endingPage "591" @default.
• W2093570206 startingPage "584" @default.
• W2093570206 abstract "Activation of cannabinoid CB(2) receptors suppresses neuropathic pain induced by traumatic nerve injury. The present studies were conducted to evaluate the efficacy of cannabinoid CB(2) receptor activation in suppressing painful peripheral neuropathy evoked by chemotherapeutic treatment with the antitumor agent paclitaxel. Rats received paclitaxel (2 mg/kg i.p./day) on 4 alternate days to induce mechanical hypersensitivity (mechanical allodynia). Mechanical allodynia was defined as a lowering of the threshold for paw withdrawal to stimulation of the plantar hind paw surface with an electronic von Frey stimulator. Mechanical allodynia developed in paclitaxel-treated animals relative to groups receiving the Cremophor EL/ethanol/saline vehicle at the same times. Two structurally distinct cannabinoid CB(2) agonists, the aminoalkylindole (R,S)-AM1241 [(R,S)-(2-iodo-5-nitrophenyl)-[1-((1-methyl-piperidin-2-yl)methyl)-1H-indol-3-yl]-methanone] and the cannabilactone AM1714 (1,9-dihydroxy-3-(1',1'-dimethylheptyl)-6H-benzo[c]chromene-6-one), produced a dose-related suppression of established paclitaxel-evoked mechanical allodynia after systemic administration. Pretreatment with the CB(2) antagonist SR144528 [5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide], but not the CB(1) antagonist SR141716 [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide], blocked the antiallodynic effects of both (R,S)-AM1241 and AM1714. Moreover, (R)-AM1241, but not (S)-AM1241, suppressed paclitaxel-evoked mechanical allodynia relative to either vehicle treatment or preinjection thresholds, consistent with mediation by CB(2). Administration of either the CB(1) or CB(2) antagonist alone failed to alter paclitaxel-evoked mechanical allodynia. Moreover, (R,S)-AM1241 did not alter paw withdrawal thresholds in rats that received the Cremophor EL vehicle in lieu of paclitaxel, whereas AM1714 induced a modest antinociceptive effect. Our data suggest that cannabinoid CB(2) receptors may be important therapeutic targets for the treatment of chemotherapy-evoked neuropathy." @default.
• W2093570206 created "2016-06-24" @default.
• W2093570206 creator A5000540926 @default.
• W2093570206 creator A5012489562 @default.
• W2093570206 creator A5053771806 @default.
• W2093570206 creator A5061500959 @default.
• W2093570206 creator A5071641808 @default.
• W2093570206 creator A5082964334 @default.
• W2093570206 date "2008-07-29" @default.
• W2093570206 modified "2023-10-08" @default.
• W2093570206 title "Selective Activation of Cannabinoid CB₂ Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats" @default.
• W2093570206 cites W1495173924 @default.
• W2093570206 cites W1542530495 @default.
• W2093570206 cites W1578820780 @default.
• W2093570206 cites W1964037009 @default.
• W2093570206 cites W1968426375 @default.
• W2093570206 cites W1968446992 @default.
• W2093570206 cites W1972510628 @default.
• W2093570206 cites W1974542461 @default.
• W2093570206 cites W1980562969 @default.
• W2093570206 cites W1990267117 @default.
• W2093570206 cites W1991677710 @default.
• W2093570206 cites W1993407667 @default.
• W2093570206 cites W1995048478 @default.
• W2093570206 cites W1999808927 @default.
• W2093570206 cites W2001196318 @default.
• W2093570206 cites W2008907688 @default.
• W2093570206 cites W2025055783 @default.
• W2093570206 cites W2028312992 @default.
• W2093570206 cites W2036912145 @default.
• W2093570206 cites W2038770419 @default.
• W2093570206 cites W2046392540 @default.
• W2093570206 cites W2048739847 @default.
• W2093570206 cites W2049213018 @default.
• W2093570206 cites W2056188558 @default.
• W2093570206 cites W2068112218 @default.
• W2093570206 cites W2070535004 @default.
• W2093570206 cites W2076257628 @default.
• W2093570206 cites W2079790110 @default.
• W2093570206 cites W2081406767 @default.
• W2093570206 cites W2082237701 @default.
• W2093570206 cites W2086434606 @default.
• W2093570206 cites W2088568499 @default.
• W2093570206 cites W2094267095 @default.
• W2093570206 cites W2102551452 @default.
• W2093570206 cites W2114826333 @default.
• W2093570206 cites W2128848742 @default.
• W2093570206 cites W2131762605 @default.
• W2093570206 cites W2133551580 @default.
• W2093570206 cites W24381337 @default.
• W2093570206 doi "https://doi.org/10.1124/jpet.108.141994" @default.
• W2093570206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2682949" @default.
• W2093570206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18664590" @default.
• W2093570206 hasPublicationYear "2008" @default.
• W2093570206 type Work @default.
• W2093570206 sameAs 2093570206 @default.
• W2093570206 citedByCount "100" @default.
• W2093570206 countsByYear W20935702062012 @default.
• W2093570206 countsByYear W20935702062013 @default.
• W2093570206 countsByYear W20935702062014 @default.
• W2093570206 countsByYear W20935702062015 @default.
• W2093570206 countsByYear W20935702062016 @default.
• W2093570206 countsByYear W20935702062017 @default.
• W2093570206 countsByYear W20935702062018 @default.
• W2093570206 countsByYear W20935702062019 @default.
• W2093570206 countsByYear W20935702062020 @default.
• W2093570206 countsByYear W20935702062021 @default.
• W2093570206 countsByYear W20935702062022 @default.
• W2093570206 countsByYear W20935702062023 @default.
• W2093570206 crossrefType "journal-article" @default.
• W2093570206 hasAuthorship W2093570206A5000540926 @default.
• W2093570206 hasAuthorship W2093570206A5012489562 @default.
• W2093570206 hasAuthorship W2093570206A5053771806 @default.
• W2093570206 hasAuthorship W2093570206A5061500959 @default.
• W2093570206 hasAuthorship W2093570206A5071641808 @default.
• W2093570206 hasAuthorship W2093570206A5082964334 @default.
• W2093570206 hasBestOaLocation W20935702062 @default.
• W2093570206 hasConcept C126322002 @default.
• W2093570206 hasConcept C148001335 @default.
• W2093570206 hasConcept C15490471 @default.
• W2093570206 hasConcept C170493617 @default.
• W2093570206 hasConcept C185592680 @default.
• W2093570206 hasConcept C2776694085 @default.
• W2093570206 hasConcept C2776885963 @default.
• W2093570206 hasConcept C2777107010 @default.
• W2093570206 hasConcept C2777292972 @default.
• W2093570206 hasConcept C2777883359 @default.
• W2093570206 hasConcept C2779245659 @default.
• W2093570206 hasConcept C2780433416 @default.
• W2093570206 hasConcept C2780871563 @default.
• W2093570206 hasConcept C71924100 @default.
• W2093570206 hasConcept C93248783 @default.
• W2093570206 hasConcept C98274493 @default.
• W2093570206 hasConceptScore W2093570206C126322002 @default.
• W2093570206 hasConceptScore W2093570206C148001335 @default.
• W2093570206 hasConceptScore W2093570206C15490471 @default.
• W2093570206 hasConceptScore W2093570206C170493617 @default.
• W2093570206 hasConceptScore W2093570206C185592680 @default.

• next