Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093573404> ?p ?o ?g. }
- W2093573404 endingPage "e83403" @default.
- W2093573404 startingPage "e83403" @default.
- W2093573404 abstract "Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) lead to significant cardiovascular morbidity and mortality worldwide. Mutations in the genes encoding the sarcomere, the force-generating unit in the cardiomyocyte, cause familial forms of both HCM and DCM. This study examines two HCM-causing (I79N, E163K) and two DCM-causing (R141W, R173W) mutations in the troponin T subunit of the troponin complex using human β-cardiac myosin. Unlike earlier reports using various myosin constructs, we found that none of these mutations affect the maximal sliding velocities or maximal Ca(2+)-activated ADP release rates involving the thin filament human β-cardiac myosin complex. Changes in Ca(2+) sensitivity using the human myosin isoform do, however, mimic changes seen previously with non-human myosin isoforms. Transient kinetic measurements show that these mutations alter the kinetics of Ca(2+) induced conformational changes in the regulatory thin filament proteins. These changes in calcium sensitivity are independent of active, cycling human β-cardiac myosin." @default.
- W2093573404 created "2016-06-24" @default.
- W2093573404 creator A5004015424 @default.
- W2093573404 creator A5010664738 @default.
- W2093573404 creator A5049037453 @default.
- W2093573404 creator A5068718671 @default.
- W2093573404 creator A5070571802 @default.
- W2093573404 creator A5072173854 @default.
- W2093573404 date "2013-12-18" @default.
- W2093573404 modified "2023-09-26" @default.
- W2093573404 title "Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin" @default.
- W2093573404 cites W131138613 @default.
- W2093573404 cites W1416357203 @default.
- W2093573404 cites W1481760785 @default.
- W2093573404 cites W1486373758 @default.
- W2093573404 cites W1507872541 @default.
- W2093573404 cites W1544291524 @default.
- W2093573404 cites W1547857055 @default.
- W2093573404 cites W1570988578 @default.
- W2093573404 cites W1901823973 @default.
- W2093573404 cites W1969047020 @default.
- W2093573404 cites W1982752211 @default.
- W2093573404 cites W1984848351 @default.
- W2093573404 cites W1985540942 @default.
- W2093573404 cites W1992924616 @default.
- W2093573404 cites W1995697852 @default.
- W2093573404 cites W1996547062 @default.
- W2093573404 cites W2016984612 @default.
- W2093573404 cites W2017535186 @default.
- W2093573404 cites W2018747164 @default.
- W2093573404 cites W2034477007 @default.
- W2093573404 cites W2036466774 @default.
- W2093573404 cites W2037615332 @default.
- W2093573404 cites W203930211 @default.
- W2093573404 cites W2039365607 @default.
- W2093573404 cites W2040635619 @default.
- W2093573404 cites W2041405839 @default.
- W2093573404 cites W2041856019 @default.
- W2093573404 cites W2045156603 @default.
- W2093573404 cites W2046993766 @default.
- W2093573404 cites W2057096287 @default.
- W2093573404 cites W2059111747 @default.
- W2093573404 cites W2060945464 @default.
- W2093573404 cites W2066089111 @default.
- W2093573404 cites W2071230984 @default.
- W2093573404 cites W2073958794 @default.
- W2093573404 cites W2074639418 @default.
- W2093573404 cites W2076438593 @default.
- W2093573404 cites W2080941696 @default.
- W2093573404 cites W2082771153 @default.
- W2093573404 cites W2083087816 @default.
- W2093573404 cites W2086554842 @default.
- W2093573404 cites W2092448879 @default.
- W2093573404 cites W2092580015 @default.
- W2093573404 cites W2096913221 @default.
- W2093573404 cites W2102627192 @default.
- W2093573404 cites W2103715799 @default.
- W2093573404 cites W2111411807 @default.
- W2093573404 cites W2115783430 @default.
- W2093573404 cites W2118238916 @default.
- W2093573404 cites W2118344440 @default.
- W2093573404 cites W2119010804 @default.
- W2093573404 cites W2121936157 @default.
- W2093573404 cites W2127423627 @default.
- W2093573404 cites W2133680467 @default.
- W2093573404 cites W2138427242 @default.
- W2093573404 cites W2140177925 @default.
- W2093573404 cites W2142388130 @default.
- W2093573404 cites W2144456068 @default.
- W2093573404 cites W2149422196 @default.
- W2093573404 cites W2160416495 @default.
- W2093573404 cites W2161676629 @default.
- W2093573404 cites W2162635257 @default.
- W2093573404 cites W2169612678 @default.
- W2093573404 cites W2188384252 @default.
- W2093573404 cites W4297917728 @default.
- W2093573404 cites W52025651 @default.
- W2093573404 doi "https://doi.org/10.1371/journal.pone.0083403" @default.
- W2093573404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3867432" @default.
- W2093573404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24367593" @default.
- W2093573404 hasPublicationYear "2013" @default.
- W2093573404 type Work @default.
- W2093573404 sameAs 2093573404 @default.
- W2093573404 citedByCount "52" @default.
- W2093573404 countsByYear W20935734042014 @default.
- W2093573404 countsByYear W20935734042015 @default.
- W2093573404 countsByYear W20935734042016 @default.
- W2093573404 countsByYear W20935734042017 @default.
- W2093573404 countsByYear W20935734042018 @default.
- W2093573404 countsByYear W20935734042019 @default.
- W2093573404 countsByYear W20935734042020 @default.
- W2093573404 countsByYear W20935734042021 @default.
- W2093573404 countsByYear W20935734042022 @default.
- W2093573404 countsByYear W20935734042023 @default.
- W2093573404 crossrefType "journal-article" @default.
- W2093573404 hasAuthorship W2093573404A5004015424 @default.
- W2093573404 hasAuthorship W2093573404A5010664738 @default.
- W2093573404 hasAuthorship W2093573404A5049037453 @default.