FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093577650> ?p ?o ?g. }

• W2093577650 endingPage "1476" @default.
• W2093577650 startingPage "1466" @default.
• W2093577650 abstract "Objective— At sites of vascular injury, thrombin is an important mediator in thrombus growth and stability. Using microfluidic flow devices as well as patterned surfaces of collagen and tissue factor (TF), we sought to determine the role that fibrin plays in clot stability without interfering with the production of thrombin. Methods and Results— We deployed an 8-channel microfluidic device to study coagulation during corn trypsin inhibitor–treated (XIIa-inhibited) whole blood perfusion over lipidated TF linked to a fibrillar collagen type 1 surface. Clot growth and embolization were measured at initial inlet venous (200 s −1 ) or arterial (1000 s −1 ) wall shear rates under constant flow rate or pressure relief mode in the presence or absence of Gly-Pro-Arg-Pro (GPRP) to block fibrin polymerization. Numerical calculations for each mode defined hemodynamic forces on the growing thrombi. In either mode at inlet venous flow, increasing amounts of TF on the surface led to a modest dose-dependent increase (up to 2-fold) in platelet deposition, but resulted in massive fibrin accumulation (>50-fold) only when exceeding a critical TF threshold. At a venous inlet flow, GPRP led to a slight 20% increase in platelet accumulation ( P <0.01) in pressure relief mode with thrombi resisting ≈1500 s −1 before full channel occlusion. GPRP-treated thrombi were unstable under constant flow rate, where shear forces caused embolization at a maximum shear rate of ≈2300 s −1 (69 dynes/cm2). In constant flow rate mode, the nonocclusive platelet-fibrin deposits (no GPRP) withstood maximum shear rates of ≈29 000 s −1 (870 dyne/cm2) at ≈95% of full channel occlusion. For arterial inlet shear rate, embolization was marked for either mode with GPRP present when shear forces reached 87 dynes/cm2 (≈2900 s −1 ). Under constant flow rate, platelet-fibrin deposits (no GPRP) withstood maximums of 2400 dynes/cm2 (80,000 s −1 ) at ≈90% of full channel occlusion prior to embolization. Conclusion— Fibrin increased clot strength by 12- to 28-fold. Under pressure relief mode, ≈2-fold more fibrin was produced under venous flow ( P <0.001). These studies define embolization criteria for clots formed with surface TF-triggered thrombin production (±fibrin) under venous and arterial flows." @default.
• W2093577650 created "2016-06-24" @default.
• W2093577650 creator A5019405351 @default.
• W2093577650 creator A5039986449 @default.
• W2093577650 creator A5065179734 @default.
• W2093577650 date "2012-06-01" @default.
• W2093577650 modified "2023-10-16" @default.
• W2093577650 title "Thrombus Growth and Embolism on Tissue Factor-Bearing Collagen Surfaces Under Flow" @default.
• W2093577650 cites W1581427725 @default.
• W2093577650 cites W1967652100 @default.
• W2093577650 cites W1970531209 @default.
• W2093577650 cites W1980877776 @default.
• W2093577650 cites W1998762602 @default.
• W2093577650 cites W2004336126 @default.
• W2093577650 cites W2006508040 @default.
• W2093577650 cites W2009172994 @default.
• W2093577650 cites W2022078390 @default.
• W2093577650 cites W2023122926 @default.
• W2093577650 cites W2025015037 @default.
• W2093577650 cites W2034921547 @default.
• W2093577650 cites W2036904069 @default.
• W2093577650 cites W2042549988 @default.
• W2093577650 cites W2043588253 @default.
• W2093577650 cites W2045683734 @default.
• W2093577650 cites W2058161894 @default.
• W2093577650 cites W2061936528 @default.
• W2093577650 cites W2077012341 @default.
• W2093577650 cites W2083733554 @default.
• W2093577650 cites W2087501332 @default.
• W2093577650 cites W2090978644 @default.
• W2093577650 cites W2127946991 @default.
• W2093577650 cites W2128602721 @default.
• W2093577650 cites W2130801240 @default.
• W2093577650 cites W2132006345 @default.
• W2093577650 cites W2132612915 @default.
• W2093577650 cites W2137827663 @default.
• W2093577650 cites W2138328550 @default.
• W2093577650 doi "https://doi.org/10.1161/atvbaha.112.249789" @default.
• W2093577650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3418805" @default.
• W2093577650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22516070" @default.
• W2093577650 hasPublicationYear "2012" @default.
• W2093577650 type Work @default.
• W2093577650 sameAs 2093577650 @default.
• W2093577650 citedByCount "117" @default.
• W2093577650 countsByYear W20935776502012 @default.
• W2093577650 countsByYear W20935776502013 @default.
• W2093577650 countsByYear W20935776502014 @default.
• W2093577650 countsByYear W20935776502015 @default.
• W2093577650 countsByYear W20935776502016 @default.
• W2093577650 countsByYear W20935776502017 @default.
• W2093577650 countsByYear W20935776502018 @default.
• W2093577650 countsByYear W20935776502019 @default.
• W2093577650 countsByYear W20935776502020 @default.
• W2093577650 countsByYear W20935776502021 @default.
• W2093577650 countsByYear W20935776502022 @default.
• W2093577650 countsByYear W20935776502023 @default.
• W2093577650 crossrefType "journal-article" @default.
• W2093577650 hasAuthorship W2093577650A5019405351 @default.
• W2093577650 hasAuthorship W2093577650A5039986449 @default.
• W2093577650 hasAuthorship W2093577650A5065179734 @default.
• W2093577650 hasBestOaLocation W20935776501 @default.
• W2093577650 hasConcept C12554922 @default.
• W2093577650 hasConcept C126322002 @default.
• W2093577650 hasConcept C136229726 @default.
• W2093577650 hasConcept C141071460 @default.
• W2093577650 hasConcept C158846371 @default.
• W2093577650 hasConcept C178853913 @default.
• W2093577650 hasConcept C185592680 @default.
• W2093577650 hasConcept C192562407 @default.
• W2093577650 hasConcept C203014093 @default.
• W2093577650 hasConcept C2776035437 @default.
• W2093577650 hasConcept C2777292125 @default.
• W2093577650 hasConcept C2780868729 @default.
• W2093577650 hasConcept C2781362458 @default.
• W2093577650 hasConcept C54173615 @default.
• W2093577650 hasConcept C71924100 @default.
• W2093577650 hasConcept C86803240 @default.
• W2093577650 hasConcept C89560881 @default.
• W2093577650 hasConceptScore W2093577650C12554922 @default.
• W2093577650 hasConceptScore W2093577650C126322002 @default.
• W2093577650 hasConceptScore W2093577650C136229726 @default.
• W2093577650 hasConceptScore W2093577650C141071460 @default.
• W2093577650 hasConceptScore W2093577650C158846371 @default.
• W2093577650 hasConceptScore W2093577650C178853913 @default.
• W2093577650 hasConceptScore W2093577650C185592680 @default.
• W2093577650 hasConceptScore W2093577650C192562407 @default.
• W2093577650 hasConceptScore W2093577650C203014093 @default.
• W2093577650 hasConceptScore W2093577650C2776035437 @default.
• W2093577650 hasConceptScore W2093577650C2777292125 @default.
• W2093577650 hasConceptScore W2093577650C2780868729 @default.
• W2093577650 hasConceptScore W2093577650C2781362458 @default.
• W2093577650 hasConceptScore W2093577650C54173615 @default.
• W2093577650 hasConceptScore W2093577650C71924100 @default.
• W2093577650 hasConceptScore W2093577650C86803240 @default.
• W2093577650 hasConceptScore W2093577650C89560881 @default.
• W2093577650 hasIssue "6" @default.
• W2093577650 hasLocation W20935776501 @default.
• W2093577650 hasLocation W20935776502 @default.

• next