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- W2093581964 abstract "Abstract— The neuroleptic phenothiazine derivative chlorpromazine (CPZ) at high concentration (1 × 10−5 M) decreased either the phasic or tonic contraction in response to carbachol and the carbachol-induced increase in [Ca2+]i in both phases in ileal muscle. In contrast, CPZ at low concentrations (8 × 10−7 – 5 × 10−6 M) decreased only the phasic contraction and potentiated the tonic contraction induced by carbachol. However, CPZ at these concentrations dose-dependently decreased the carbachol-induced increase in [Ca2+]i in both phases. These results suggested that CPZ dose-dependently decreased the initial phasic contraction in response to carbachol by inhibition of Ca2+ release from the intracellular storage sites. CPZ at low concentrations appears to increase Ca2+ sensitivity to contractile proteins in the carbachol-induced tonic phase. CPZ dose-dependently reduced the 60 mM K+-induced phasic and tonic responses and a concomitant decrease in [Ca2+]i in ileal muscle." @default.
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- W2093581964 date "2000-05-06" @default.
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- W2093581964 title "Chlorpromazine at comparatively low concentrations potentiates carbachol-induced tonic contraction of ileal longitudinal smooth muscle of the guinea-pig" @default.
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- W2093581964 doi "https://doi.org/10.1111/j.1472-8206.2000.tb00015.x" @default.
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