Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093583591> ?p ?o ?g. }
- W2093583591 endingPage "14" @default.
- W2093583591 startingPage "1" @default.
- W2093583591 abstract "Wild-type and HIF1α −/− MEF cells were used to determine the role of HIF1α in cadmium-induced toxicity. Cadmium treatment did not affect HIF1-mediated transcription but led to caspase activation and apoptotic cell death in wild-type and HIF1α −/− cells. Cadmium-induced cell death, however, was significantly higher in HIF1α −/− cells as compared to their wild-type counterparts. Increased cell death in the HIF1α −/− cells was correlated with lower metallothionein protein, elevated levels of reactive oxygen species, and decreased superoxide dismutase enzyme activity. The total and oxidized glutathione levels, and, correspondingly, lipid peroxidation levels were elevated in the null cells compared to wild-type cells, indicating increased antioxidant demand and greater oxidative stress. Overall, the results suggest that basal levels of HIF1α play a protective role against cadmium-induced cytotoxicity in mouse embryonic fibroblasts by maintaining metallothionein and antioxidant activity levels." @default.
- W2093583591 created "2016-06-24" @default.
- W2093583591 creator A5010942908 @default.
- W2093583591 creator A5066288954 @default.
- W2093583591 creator A5087843518 @default.
- W2093583591 date "2011-01-01" @default.
- W2093583591 modified "2023-09-24" @default.
- W2093583591 title "The Loss of HIF1αLeads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts" @default.
- W2093583591 cites W1486970902 @default.
- W2093583591 cites W1548204775 @default.
- W2093583591 cites W1723790989 @default.
- W2093583591 cites W1749022239 @default.
- W2093583591 cites W1902785172 @default.
- W2093583591 cites W1913373831 @default.
- W2093583591 cites W1968438943 @default.
- W2093583591 cites W1980091365 @default.
- W2093583591 cites W1989673862 @default.
- W2093583591 cites W1990811092 @default.
- W2093583591 cites W1997191759 @default.
- W2093583591 cites W1997934335 @default.
- W2093583591 cites W1998938457 @default.
- W2093583591 cites W2004731363 @default.
- W2093583591 cites W2005868568 @default.
- W2093583591 cites W2006342727 @default.
- W2093583591 cites W2013500629 @default.
- W2093583591 cites W2013948741 @default.
- W2093583591 cites W2017924999 @default.
- W2093583591 cites W2020189193 @default.
- W2093583591 cites W2021656373 @default.
- W2093583591 cites W2022451432 @default.
- W2093583591 cites W2025974453 @default.
- W2093583591 cites W2026093245 @default.
- W2093583591 cites W2033958147 @default.
- W2093583591 cites W2036366834 @default.
- W2093583591 cites W2037434205 @default.
- W2093583591 cites W2042216712 @default.
- W2093583591 cites W2042278941 @default.
- W2093583591 cites W2048563316 @default.
- W2093583591 cites W2052505432 @default.
- W2093583591 cites W2057614400 @default.
- W2093583591 cites W2058421811 @default.
- W2093583591 cites W2059501279 @default.
- W2093583591 cites W2059626762 @default.
- W2093583591 cites W2061488891 @default.
- W2093583591 cites W2068049375 @default.
- W2093583591 cites W2071829959 @default.
- W2093583591 cites W2075054245 @default.
- W2093583591 cites W2077644908 @default.
- W2093583591 cites W2077714606 @default.
- W2093583591 cites W2089141914 @default.
- W2093583591 cites W2095467825 @default.
- W2093583591 cites W2101952777 @default.
- W2093583591 cites W2113620806 @default.
- W2093583591 cites W2118894711 @default.
- W2093583591 cites W2125847914 @default.
- W2093583591 cites W2127732086 @default.
- W2093583591 cites W2129400442 @default.
- W2093583591 cites W2131118500 @default.
- W2093583591 cites W2136137056 @default.
- W2093583591 cites W2140665078 @default.
- W2093583591 cites W2141528928 @default.
- W2093583591 cites W2144625075 @default.
- W2093583591 cites W2145023430 @default.
- W2093583591 cites W2153512434 @default.
- W2093583591 cites W2159285818 @default.
- W2093583591 cites W2168929079 @default.
- W2093583591 cites W2171296382 @default.
- W2093583591 doi "https://doi.org/10.1155/2011/391074" @default.
- W2093583591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3147003" @default.
- W2093583591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21811500" @default.
- W2093583591 hasPublicationYear "2011" @default.
- W2093583591 type Work @default.
- W2093583591 sameAs 2093583591 @default.
- W2093583591 citedByCount "0" @default.
- W2093583591 crossrefType "journal-article" @default.
- W2093583591 hasAuthorship W2093583591A5010942908 @default.
- W2093583591 hasAuthorship W2093583591A5066288954 @default.
- W2093583591 hasAuthorship W2093583591A5087843518 @default.
- W2093583591 hasBestOaLocation W20935835911 @default.
- W2093583591 hasConcept C104317684 @default.
- W2093583591 hasConcept C109316439 @default.
- W2093583591 hasConcept C143065580 @default.
- W2093583591 hasConcept C145103041 @default.
- W2093583591 hasConcept C153911025 @default.
- W2093583591 hasConcept C178790620 @default.
- W2093583591 hasConcept C181199279 @default.
- W2093583591 hasConcept C185592680 @default.
- W2093583591 hasConcept C190283241 @default.
- W2093583591 hasConcept C202751555 @default.
- W2093583591 hasConcept C20719415 @default.
- W2093583591 hasConcept C207583985 @default.
- W2093583591 hasConcept C2775838275 @default.
- W2093583591 hasConcept C2776151105 @default.
- W2093583591 hasConcept C2778004101 @default.
- W2093583591 hasConcept C2778643788 @default.
- W2093583591 hasConcept C2780829032 @default.
- W2093583591 hasConcept C29730261 @default.
- W2093583591 hasConcept C31573885 @default.