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• W2093584047 abstract "Mammalian mitochondria are known to proliferate in response to several stimuli. Proliferation requires an increase in expression of genes encoding proteins involved in mitochondrial biogenesis, as well as in the replication and expression of mitochondrial DNA (mtDNA). In contrast, we report that inhibiting mitochondrial protein synthesis causes a modulation in mtDNA gene expression without the concomitant increase in proliferative markers. Further, inhibition results in the production of a previously unidentified light-strand mitochondrial RNA that spans the entire displacement loop, the function of which is currently unknown." @default.
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• W2093584047 date "2001-04-10" @default.
• W2093584047 modified "2023-09-26" @default.
• W2093584047 title "Inhibition of mitochondrial protein synthesis promotes autonomous regulation of mtDNA expression and generation of a new mitochondrial RNA species" @default.
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• W2093584047 doi "https://doi.org/10.1016/s0014-5793(01)02345-6" @default.
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