FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093584619> ?p ?o ?g. }

• W2093584619 endingPage "384" @default.
• W2093584619 startingPage "375" @default.
• W2093584619 abstract "Perivascular macrophages are believed to have a significant role in inflammation in the central nervous system (CNS). They express a number of different receptors that point toward functions in both innate immunity, through pathogen-associated molecular pattern recognition, phagocytosis, and cytokine responsiveness, and acquired immunity, through antigen presentation and co-stimulation. We are interested in the receptors that are differentially expressed by perivascular macrophages and microglia in both the normal CNS as well as in neuroinflammation and neurodegeneration. In this article we report the use of a well-characterized monoclonal antibody, 5D3, to localize the expression of the mannose receptor to perivascular macrophages in the normal CNS and in various models of brain pathology. Mannose receptor expression was limited to perivascular, meningeal, and choroid plexus macrophages in normal, inflamed, injured, and diseased CNS. In particular, activated microglia and invading hematogenous leukocytes were mannose receptor negative while expressing the F4/80 antigen, macrosialin (CD68), FcRII (CD32), scavenger receptor (CD204), and CR3 (CD11b/CD18). Since the perivascular macrophages expressing the mannose receptor are known to be the only constitutively phagocytic cells in the normal CNS, we injected clodronate-loaded liposomes intracerebroventricularly in control mice to deplete these cells. In these mice, there was no detectable mannose receptor expression in perivascular spaces after immunocytochemistry with the 5D3 monoclonal antibody. This finding underlines the value of the monoclonal antibody 5D3 as a tool to study murine perivascular macrophages selectively. Mannose receptor expression by macrophages located at blood-brain (perivascular), brain-cerebrospinal fluid (CSF) (meningeal), and CSF-blood (choroid plexus) interfaces supports a functional role of these cells in responding to external stimuli such as infection. © 2004 Wiley-Liss, Inc." @default.
• W2093584619 created "2016-06-24" @default.
• W2093584619 creator A5008325892 @default.
• W2093584619 creator A5022720002 @default.
• W2093584619 creator A5038952654 @default.
• W2093584619 creator A5044019815 @default.
• W2093584619 creator A5061878537 @default.
• W2093584619 creator A5079003683 @default.
• W2093584619 date "2004-01-01" @default.
• W2093584619 modified "2023-10-16" @default.
• W2093584619 title "Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain" @default.
• W2093584619 cites W1535567348 @default.
• W2093584619 cites W1965610289 @default.
• W2093584619 cites W1970773611 @default.
• W2093584619 cites W1972879829 @default.
• W2093584619 cites W1973238005 @default.
• W2093584619 cites W1975326767 @default.
• W2093584619 cites W1979425342 @default.
• W2093584619 cites W1980113215 @default.
• W2093584619 cites W1984801123 @default.
• W2093584619 cites W1988113419 @default.
• W2093584619 cites W1988434678 @default.
• W2093584619 cites W1993221927 @default.
• W2093584619 cites W1993262247 @default.
• W2093584619 cites W1993677761 @default.
• W2093584619 cites W1998907409 @default.
• W2093584619 cites W2000976612 @default.
• W2093584619 cites W2002586787 @default.
• W2093584619 cites W2005648670 @default.
• W2093584619 cites W2010486222 @default.
• W2093584619 cites W2012765108 @default.
• W2093584619 cites W2014187431 @default.
• W2093584619 cites W2014324389 @default.
• W2093584619 cites W2014740158 @default.
• W2093584619 cites W2024248428 @default.
• W2093584619 cites W2025970341 @default.
• W2093584619 cites W2036931179 @default.
• W2093584619 cites W2038030879 @default.
• W2093584619 cites W2050235826 @default.
• W2093584619 cites W2059666688 @default.
• W2093584619 cites W2065411239 @default.
• W2093584619 cites W2072274398 @default.
• W2093584619 cites W2076407459 @default.
• W2093584619 cites W2077489685 @default.
• W2093584619 cites W2079342890 @default.
• W2093584619 cites W2082798955 @default.
• W2093584619 cites W2085402104 @default.
• W2093584619 cites W2085632366 @default.
• W2093584619 cites W2087402752 @default.
• W2093584619 cites W2094831632 @default.
• W2093584619 cites W2120380490 @default.
• W2093584619 cites W2127648758 @default.
• W2093584619 cites W2133519004 @default.
• W2093584619 cites W2157699006 @default.
• W2093584619 cites W2160720714 @default.
• W2093584619 cites W2162472958 @default.
• W2093584619 cites W2163640760 @default.
• W2093584619 cites W2168907606 @default.
• W2093584619 cites W2184434686 @default.
• W2093584619 cites W2460284700 @default.
• W2093584619 doi "https://doi.org/10.1002/glia.20124" @default.
• W2093584619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15538754" @default.
• W2093584619 hasPublicationYear "2004" @default.
• W2093584619 type Work @default.
• W2093584619 sameAs 2093584619 @default.
• W2093584619 citedByCount "153" @default.
• W2093584619 countsByYear W20935846192012 @default.
• W2093584619 countsByYear W20935846192013 @default.
• W2093584619 countsByYear W20935846192014 @default.
• W2093584619 countsByYear W20935846192015 @default.
• W2093584619 countsByYear W20935846192016 @default.
• W2093584619 countsByYear W20935846192017 @default.
• W2093584619 countsByYear W20935846192018 @default.
• W2093584619 countsByYear W20935846192019 @default.
• W2093584619 countsByYear W20935846192020 @default.
• W2093584619 countsByYear W20935846192021 @default.
• W2093584619 countsByYear W20935846192022 @default.
• W2093584619 countsByYear W20935846192023 @default.
• W2093584619 crossrefType "journal-article" @default.
• W2093584619 hasAuthorship W2093584619A5008325892 @default.
• W2093584619 hasAuthorship W2093584619A5022720002 @default.
• W2093584619 hasAuthorship W2093584619A5038952654 @default.
• W2093584619 hasAuthorship W2093584619A5044019815 @default.
• W2093584619 hasAuthorship W2093584619A5061878537 @default.
• W2093584619 hasAuthorship W2093584619A5079003683 @default.
• W2093584619 hasBestOaLocation W20935846192 @default.
• W2093584619 hasConcept C105702510 @default.
• W2093584619 hasConcept C134018914 @default.
• W2093584619 hasConcept C142724271 @default.
• W2093584619 hasConcept C159654299 @default.
• W2093584619 hasConcept C169760540 @default.
• W2093584619 hasConcept C170493617 @default.
• W2093584619 hasConcept C202751555 @default.
• W2093584619 hasConcept C203014093 @default.
• W2093584619 hasConcept C2776205754 @default.
• W2093584619 hasConcept C2776538271 @default.
• W2093584619 hasConcept C2776914184 @default.
• W2093584619 hasConcept C2777799939 @default.

• next