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- W2093584890 abstract "15-deoxy-Delta12,14-PGJ2 (15d-PGJ2) has been identified as an endogenous ligand for PPARgamma, inducing adipogenesis in vitro. Additional roles for this molecule in the propagation and resolution of inflammation, ligation of NF-kappaB, and mediation of apoptosis have been proposed. However, quantitative, physiochemical evidence for the formation of 15d-PGJ2 in vivo is lacking. We report that 15d-PGJ2 is detectable using liquid chromatography-mass spectrometry-mass spectrometry at low picomolar concentrations in the medium of 3T3-L1 preadipocytes. However, despite induction of COX-2, production of PGs, including 15d-PGJ2, does not increase during adipocyte differentiation, a process unaltered by COX inhibition. 15d-PGJ2 is detectable as a minor product of COX-2 in human urine. However, its biosynthesis is unaltered during or after COX activation in vivo by LPS. Furthermore, the biosynthesis of 15d-PGJ2 is not augmented in the joint fluid of patients with arthritis, nor is its urinary excretion increased in patients with diabetes or obesity. 15d-PGJ2 is not the endogenous mediator of PPARgamma-dependent adipocyte activation and is unaltered in clinical settings in which PPARgamma activation has been implicated." @default.
- W2093584890 created "2016-06-24" @default.
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- W2093584890 date "2003-09-15" @default.
- W2093584890 modified "2023-10-17" @default.
- W2093584890 title "Biosynthesis of 15-deoxy-Δ12,14-PGJ2 and the ligation of PPARγ" @default.
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- W2093584890 doi "https://doi.org/10.1172/jci18012" @default.
- W2093584890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/193665" @default.
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